【TPM1】重组人原肌球蛋白-1/【TPM1】重组人原肌球蛋

产品名称：【TPM1】重组人原肌球蛋白-1-Recombinant Human Tropomyosin-1

产品货号：PRO-469

产品规格：10ug///1mg///2ug

来源宿主：大肠杆菌中重组表达

保存建议：【TPM1】重组人原肌球蛋白-1-Recombinant Human Tropomyosin-1Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Please avoid freeze thaw cycles.

背景资料：TPM1 is a member of the tropomyosin family which consists of a number of extremely conserved， extensively distributed 35-45 kDa actin-binding proteins that are involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin-1 is composed of 2 alpha-helical chains arranged as a coiled-coil. TPM1 is polymerized end to end alongside the two grooves of actin filaments and provides stability to the filaments. TPM1 binds to actin filaments in muscle and non-muscle cells. TPM1 also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In non-muscle cells TPM1 is implicated in stabilizing cytoskeleton actin filaments. Smooth muscle contraction is controlled by interaction with caldesmon.Alternatively spliced transcript variants encoding a range of isoforms have been described in smooth muscle and non-muscle cells. TPM1 Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues， with higher expression levels in the cardiac tissues， whereas Isoform 10 is expressed in adult and fetal cardiac tissues， but not in skeletal muscle.Mutations in the TPM1 gene are linked to type 3 familial hypertrophic cardiomyopathy.

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关键词：Recombinant Human Tropomyosin-1，【TPM1】重组人原肌球蛋白-1，TPM1