【TPM1】重组人原肌球蛋白-1,Recombinant H

【TPM1】重组人原肌球蛋白-1，Recombinant Human Tropomyosin-1，TPM1

产品名称：【TPM1】重组人原肌球蛋白-1-Recombinant Human Tropomyosin-1

产品货号：PRO-469

产品规格：1mg///2ug

来源宿主：大肠杆菌中重组表达

保存建议：【TPM1】重组人原肌球蛋白-1-Recombinant Human Tropomyosin-1Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Please avoid freeze thaw cycles.

背景资料：TPM1 is a member of the tropomyosin family which consists of a number of extremely conserved， extensively distributed 35-45 kDa actin-binding proteins that are involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin-1 is composed of 2 alpha-helical chains arranged as a coiled-coil. TPM1 is polymerized end to end alongside the two grooves of actin filaments and provides stability to the filaments. TPM1 binds to actin filaments in muscle and non-muscle cells. TPM1 also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In non-muscle cells TPM1 is implicated in stabilizing cytoskeleton actin filaments. Smooth muscle contraction is controlled by interaction with caldesmon.Alternatively spliced transcript variants encoding a range of isoforms have been described in smooth muscle and non-muscle cells. TPM1 Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues， with higher expression levels in the cardiac tissues， whereas Isoform 10 is expressed in adult and fetal cardiac tissues， but not in skeletal muscle.Mutations in the TPM1 gene are linked to type 3 familial hypertrophic cardiomyopathy.

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ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

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