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文献和实验The interaction between tyrosme phosphorylated growth-factor receptors and Src Homology 2 (SH2)-domain-containing proteins plays a critical role in growth-factor mediated signal transduction (1 ). The SH2 domains bind to receptors
Monitoring Nutrient Signaling Through the Longevity Protein p66SHC1
to nutrients through the longevity protein p66SHC1 and the mTOR/S6K cascade, which might be used to study cellular senescence and its chemical modulation by pharmaceutical agents in vitro.
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
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