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文献和实验Identifying Inhibitors of ATM and ATR Kinase Activities
The Ataxia Telangiectasia mutated (ATM) and the ATM and Rad3-related (ATR) proteins function in partially overlapping DNA damage checkpoint pathways that orchestrate the cellular response to DNA damage. Both proteins belong to a growing
A Human Cell Extract-Based Assay for the Activation of ATM and ATR Checkpoint Kinases
The Ataxia telangiectasia -mutated (ATM) and the ATM-Rad3-related (ATR) kinases are master regulators of the DNA damage-signaling pathways that respond to a wide variety of DNA damage. In this chapter, we describe an in vitro biochemical
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
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