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文献和实验张锋/曹云霞/司维/谭跃球等团队联合发现首个灵长类特异的弱畸精子症致病基因 SSX1
期刊《The American Journal of Human Genetics》上联合发表了题为 Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models 的论文成果。该研究通过全外显子测序、基因组拷贝数变异分析首次利用食蟹猴、树鼩两种动物模型,揭示了首个灵长类特异的弱畸精子症致病基因 SSX1。 该研究中
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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