N-四烯二十碳酰基-（cis-15）-D-赤型-鞘氨醇|N-

N-四烯二十碳酰基-（cis-15）-D-赤型-鞘氨醇，N-Tetracosenoyl-(cis-15)-D-erythro-sphingosine，N-Tetracosenoyl-

产品名称：N-四烯二十碳酰基-（cis-15）-D-赤型-鞘氨醇-N-Tetracosenoyl-(cis-15)-D-erythro-sphingosine

产品货号：1930-5

产品规格：5mg

背景资料：Ceramide is a fatty acid amide of sphingosine. This product is a well-defined ceramide with a tetracosenoyl (nervonyl) acyl group. Ceramide functions as a precursor in the synthesis of sphingomyelin, glycosphingolipids, and of free sphingosine and fatty acids. The sphingosine can be phosphorylated to form sphingosine-1-phosphate. Two of ceramide’s metabolites, sphingosine-1-phosphate and glucosylceramide, produce cell proliferation and other cellular functions.1 Ceramide exerts numerous biological effects, including induction of cell maturation, cell cycle arrest, terminal cell differentiation, cell senescence, and cell death.2 Because of these effects ceramide has been investigated for its use in cancer treatment and many potential approaches to cancer therapy have been presented.3 Other effects include producing reactive oxygen in mitochondria (followed by apoptosis) and stimulating phosphorylation of certain proteins (especially mitogen activated protein). It also stimulates some protein phosphatases (especially protein phosphatase 2A) making it an important controller of protein activity. Ceramides with short side chains have been shown to enter easily into cells where they are biologically active while ceramides with longer side chains will enter cells if dissolved in dodecane-isopropanol. Nervonic acid has been found to be important in the biosynthesis of nerve cell myelin and is found in sphingolipids of white matter. There is a marked reduction in the level of nervonic acid in sphingolipids in diseases involving demyelinateion, such as adrenoleukodystropy and multiple sclerosis.4

保存建议：N-四烯二十碳酰基-（cis-15）-D-赤型-鞘氨醇-N-Tetracosenoyl-(cis-15)-D-erythro-sphingosine对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：N-(cis-15)-C24:1-D-erythro-Ceramide|N-Nervonoyl-D-erythro-sphingosine

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