- $495
- Leading Biology
- United States
- APR15230G
- 2025年09月17日
- Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 克隆性：
单克隆
- 库存：
100
- 宿主：
Mouse
- 靶点：
Synthetic peptide corresponding to aa (EEEDVPGQAKDELC)of human Calreticulin
- 抗体名：
CRTC
- 规格：
50 μl
48kDa
细胞定位：
Antigen Cellular Localization: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Note=Also found in cell surface (T cells), cytosol and extracellular matrix Associated with the lytic granules in the cytolytic T-lymphocytes
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
McCauliffe D.P.,et al.J. Clin. Invest. 85:1379-1391(1990). Rokeach L.A.,et al.J. Immunol. 147:3031-3039(1991). McCauliffe D.P.,et al.J. Biol. Chem. 267:2557-2562(1992). Liu J.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CALR / Calreticulin antibody (clone 1G6A7).
功能：
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
总结：
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
联系方式：
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文献和实验The production of monoclonal antibody by hybridoma
, A., Popkov, M., Cortez, X., Fuller, R., Elia, M., Kerwin, L., and C.F. Barbas III. (2003) Rapid monoclonal antibody generation via dendritic cell targeting in vivo. Hybridoma and Hybridomics 22 (1), 23-31.
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(IgG) ELISA Kit; CSB-E11194mMouse anti-nuclear Antibody (IgG) ELISA Kit; CSB-E12912m 研究亮点 甲羟戊酸通路产物GGPP通过GGTase II催化RAB35香叶基香叶基化，促进CXCR5循环至细胞膜，维持T滤泡辅助细胞表面分子表达与分化。TCR信号经SREBP2、EGR1和E2F1增强该通路，在狼疮中异常活跃。他汀类药物抑制该通路，减轻自身免疫，提示代谢调控Tfh细胞的新机制。 05
。所以，我们建议使用微波炉或高压锅加热煮沸以达到最佳抗原修复效果。抗体：Phospho–Stat3 (Tyr705)(D3A7) XP. Rabbit mAb #9145样本：石蜡包埋人类肺部肿瘤样本煮沸设备：浴锅 (左)，微波炉 (中)，高压锅 (右)免疫染色—封闭在 IHC–P 中，我们建议在室温下在含有 Tween20 的 TBST 缓冲液和 5% 正常山羊血清 (NGS) 中封闭样品，时长 1 小时，以防止非特异性背景染色。在进行 IHC–F 时，在含有 0.3% Triton. X–100 的 1X
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