重组大鼠OSM北京厂家

特别提示：包括重组大鼠OSM在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组大鼠OSM
英文名称：Recombinant Rat Oncostatin-M
产品货号：GS4862
产品规格：2μg

分子量：Approximately 24.3kDa,a single non-glycosylated polypeptide chain containing 214 amino acids.
储存条件：冷冻（-20℃）

概述

Oncostatin-M(OSM)is a multifunctional cytokine that belongs to the Interleukin-6 subfamily.Among the family members,OSM is most closely related to leukemia inhibitory factor(LIF)and it in fact utilizes the LIF receptor in addition to its specific receptor in the human.A biologically active OSM receptor has been previously described that consists of a heterodimer of leukemia inhibitory factor receptor(LIFR)and gp130.OSM is synthesized by stimulated T-cells and monocytes.Furthermore,the effects of OSM on endothelial cells suggest a pro-inflammatory role for OSM and endothelial cells possess a large number of OSM receptors.Recombinant murine OSM contains 215 amino acids and has a molecular mass of 22.4 kDa.It has approximately 48%and 72%amino acid sequence identity with human and murine OSM.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞96%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine NIH-3T3 cells is less than 2.0ng/ml,corresponding to a specific activity of>5.0×105 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 2×PBS,0.1%Tween-80.
内毒素	Less than 1 EU/μg of rRtOSM as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	KRGCSSSSPK LLSQLKSQAN ITGNTASLLE PYILHQNLNT LTLRAACTEH PVAFPSEDML RQLSKPDFLS TVHATLGRVW HQLGAFRQQF PKIQDFPELE RARQNIQGIR NNVYCMARLL HPPLEIPEPT QADSGTSRPT TTAPGIFQIK IDSCRFLWGY HRFMGSVGRV FEEWGDGSRR SRRHSPLWAW LKGDHRIRPS RSSQSAMLRS LVPR

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