重组人OSM北京厂家

特别提示：包括重组人OSM在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人OSM
英文名称：Recombinant Human Oncostatin-M
产品货号：GS4834
产品规格：2μg

分子量：Approximately 25.8kDa,a single non-glycosylated polypeptide chain containing 227 amino acids.
储存条件：冷冻（-20℃）

概述

Oncostatin M(OSM)is a multifunctional cytokine that belongs to the Interleukin-6 subfamily.Among the family members,OSM is most closely related to leukemia inhibitory factor(LIF)and it in fact utilizes the LIF receptor in addition to its specific receptor in the human.A biologically active OSM receptor has been previously described that consists of a heterodimer of leukemia inhibitory factor receptor(LIFR)and gp130.OSM is synthesized by stimulated T-cells and monocytes.The effects of OSM on endothelial cells suggest a pro-inflammatory role for OSM and endothelial cells possess a large number of OSM receptors.Recombinant human OSM has approximately 40%and 39%amino acid sequence identity with rat and murine OSM.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 2ng/ml,corresponding to a specific activity of>5.0×105 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuOSM as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRRT RPSRKGKRLM TRGQLPR

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