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- Adipogen
- 瑞士
- AG-40B-0010-C010
- 2026年02月28日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
CD40L (human) (multimeric) (rec.)
- 保质期：
见包装说明
- 保存条件：
-20°C
- 库存：
99
- 供应商：
欣博盛生物
- 规格：
10 ug
CD40L (human) (multimeric) (rec.)产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-40B-0010-C010，包装规格是10 ug。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
MultimericCD40L™ 是一种高活性构建体，其中两个三聚体CD40配体通过ACRP30的胶原结构域人工连接。该构建体非常有效地模拟体内CD40L的天然膜辅助聚集，它是激活CD40的最有效的替代物，不需要增强剂。MultimericCD40L™ 已显示以剂量、CD40和时间依赖性方式抑制明矾诱导的IL-1β释放和胱天蛋白酶-1活化，而不影响BMDM活力。它还有效地抑制了由NLRP3激活剂触发的炎性体功能。半胱天冬酶-1非依赖性炎症介质的分泌已被证明是不变的甚至增强的。
产品详情
别名：MultimericCD40L™; ACRP30headless:CD40L; ACRP30headless:CD154; ACRP30headless:TNFSF5; ADIPOQ-CD40L
来源：CHO cells
特异性：Binds to human CD40.
浓度：0.1mg/ml after reconstitution.
分子量：~35-40kDa (SDS-PAGE)
纯度：≥95% (SDS-PAGE)
生物活性：Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml). B cell expansion online protocol available.
内毒素水平：<0.01EU/μg purified protein (LAL test, Lonza).
产品订购
|
产品名称 |
货号 |
规格 |
|
CD40L (human) (multimeric) (rec.) |
AG-40B-0010-C010 |
10 ug |
该产品自上市以来有多篇文献引用，品质有保证，以下是部分发表的文献引用：
1.Detection of alloreactive T cells from cryopreserved human peripheral blood mononuclear cells: N. Tanimine, et al.; J. Immunol. Meth. 491, 112987 (2021)
2.Sensitive identification of neoantigens and cognate TCRs in human solid tumors: M. Arnaud, et al.; Nat. Biotechnol. 40, 656 (2022)
详情请咨询Adipogen全国授权一级代理-欣博盛生物科技
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文献和实验- IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD+IgM+, post-germinal center (CD27+) human B cells: C. Werner-Favre, et al.; Eur. J. Immunol. 31, 243 (2001)
- Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003)
- Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sezary syndrome: circumvention by hexameric soluble CD40L: L.E. French, et al.; Blood 105, 219 (2005)
- Cysteine-rich Domain 1 of CD40 Mediates Receptor Self-assembly: C.R. Smulski, et al.; J. Biol. Chem. 288, 10914 (2013)
- Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay: H.B. Larman, et al.; Nucl. Acids Res. 42, 9146 (2014)
- CD4+ T Cell-derived IL-21 and deprivation of CD40 signaling favor the In Vivo development of granzyme B-expressing regulatory B cells in HIV patients: C. Kaltenmeier, et al.; J. Immunol. 194, 3768 (2015)
- Lenalidomide potentiates CD4+ CD25+ Treg-related suppression of lymphoma B-cell proliferation: M.A. Grygorowicz, et al.; Clin. Exp. Med. 17, 193 (2017)
- CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation: Ch. Jiang, et al.; Cell Rep. 28, 1307 (2019)
- Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes: J. Racle, et al.; Nat. Biotech. 37, 1283 (2019)
- Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes: C. Chong, et al.; Nat. Commun. 11, 1293 (2020)
- Biogenesis of HLA Ligand Presentation in Immune Cells Upon Activation Reveals Changes in Peptide Length Preference: F. Marino, et al.; Front. Immunol. 11, 1981 (2020)
- Detection of alloreactive T cells from cryopreserved human peripheral blood mononuclear cells: N. Tanimine, et al.; J. Immunol. Meth. 491, 112987 (2021)
- Sensitive identification of neoantigens and cognate TCRs in human solid tumors: M. Arnaud, et al.; Nat. Biotechnol. 40, 656 (2022)
, especially in the field of cancer treatment. In this chapter, a receptor localization technique is described which utilises frozen sections of human tissue and combines immunohistochemistry (IHC) and micro-autoradiography. IHC utilises antibodies tagged
Aβ-Induced Proinflammatory Cytokine Release from Differentiated Human THP-1 Monocytes
as key causative agents in AD onset, as all known mutations that lead to early onset familial AD (1 -6 ) result in an increased production of the amyloidogenic Aβ1-42 isoform (7 -11 ). Although it appears likely that the deposition of multimeric Aβ
8 The Recovery of Immunoglobulin Sequences from Single Human B Cells by Clonal Expansion
chain reaction (PCR) amplification of their variable-region genes, thereby immortalizing the VH and VL regions from individual human B cells. The method relies on the clonal expansion of single B cells in which cell-cell interactions (CD40-CD40L
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