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源叶现货试剂/标准品,库存足,周末发货Cytoscape 教程来了!快速实现顶刊同款通路网络图五大应用案例:Mustang Q 膜层析应用全解析1 个小工具,一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
96
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
VE Cadherin
- 抗体名:
血管内皮钙粘蛋白抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul/50ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
| 规格: | 50ul | 产品价格: | ¥880.0 |
英文名称 : VE Cadherin
中文名称 : 血管内皮钙粘蛋白抗体
别 名 : VE-cadherin; 7B4 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; VE Cad antibody VEC; CADH5_HUMAN.
研究领域 : 肿瘤 心血管 细胞生物 信号转导 细胞粘附分子 血管内皮细胞 内皮细胞 细胞骨架 细胞外基质
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Pig, Cow, Horse,
产品应用 : Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 81kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human VE Cadherin:251-320/784 <Extracellular>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].
Function:
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
Subunit:
Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1.
Subcellular Location:
Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.
Tissue Specificity:
Endothelial tissues and brain.
Post-translational modifications:
Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.
Similarity:
Contains 5 cadherin domains.
SWISS:
P33151
Gene ID:
1003
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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文献和实验人 血管内皮钙粘蛋白 ( VE-Ca ) 酶联免疫分析(ELISA ) 试剂盒使用说明书 本试剂仅供研究使用 目的:本试剂盒用于测定人血清,血浆及相关液体样本 中 血管内皮钙粘蛋白 (VE-Ca) 的含量。 实验原理: 本试剂盒应用双抗体夹心法测定标本中 人 血管内皮钙粘蛋白 ( VE-Ca ) 水平。用纯化的 人 血管内皮钙粘蛋白 ( VE-Ca ) 抗体 包被微孔板,制成固相抗体,往包被单抗的微孔中依次加入血管内皮钙粘
血管生成作用依赖于CCR10+内皮细胞 (Kun Yang, et al., Nature Communications, 2025) 三、AAV9血清型+Cdh5启动 Cdh5基因编码血管内皮钙粘蛋白(Cadherin-5, 也称VE-cadherin或CD144),主要在内皮细胞中表达,是血管黏附连接的关键组成部分,对于血管的正常发育必不可少。Cdh5启动子也可作为血管内皮
一、流体剪切力细胞实验背景液体是每个生物物种的重要组成部分。在生理状态下,许多细胞类型被流体环境包围。典型例子包括:血管内皮细胞,形成血管内层,淋巴管内皮细胞,形成淋巴管内层,肾和肺的上皮细胞。这种液体流动引起剪切应力,这是一种机械力,以多种方式影响细胞形态和行为。在许多标准体外实验中,细胞在没有流动的情况下培养。在这些静态条件下,通常没有考虑剪切应力依赖性细胞变化。实际上,在流动下的体外细胞培养并模拟这种机械刺激并诱导更加接近生理状态的体内生物过程行为很有意义。特别对于研究在生物流体中存在
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