Anti-CECR6 antibody

Anti-CECR6 antibody

Cat. No.     JC263424
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CECR6 rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Synthetic peptide of human CECR6
Reactivity                 Human
Content                     0.6 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CECR6
Full name                 cat eye syndrome chromosome region, candidate 6
Synonyms    
Swissprot    Q9BXQ6

Target Background
Adenosine deaminase is an enzyme that is present in most tissues and exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. A novel family of growth factors that share sequence similarity to adenosine deaminase has been identified. The cat eye syndrome critical region protein (CECR) family includes CECR1, CECR2, CECR3, CECR4, CECR5, CECR6, CECR7, CECR8 and CECR9. The genes encoding CECR proteins are candidates for Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. CES is characterized by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. CECR family members are widely expressed. Specifically, CECR1 has the highest expression in adult heart, lung, lymphoblasts and placenta. CECR2 is also involved in neurulation and chromatin remodeling. Mutations in the CECR2 gene result in neural tube defects.

Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 20-100    Predicted cell location: Nucleus
Positive control: Human lung cancer
Recommended dilution: 20-100
            
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml263424(CECR6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using ml263424(CECR6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Western blotting
Predicted band size:58 kDa
Positive control:Human heart tissue lysate 
Recommended dilution: 200-1000