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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
6894-43-5
- 规格：
1 mg/5 mg/10 mg/20 mg
| 规格： | 1 mg | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1900.0 |
| 规格： | 20 mg | 产品价格： | ￥3050.0 |
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Kahweol
CAS No. : 6894-43-5
MCE 国际站：Kahweol
产品活性：Kahweol 是咖啡 Coffea Arabica 的成分之一，具有抗炎，抗血管生成和抗癌活性。Kahweol 通过激酶 (AMPK) 的活化抑制的脂肪生成 adipogenesis 和增加葡萄糖摄取。Kahweol 诱导细胞凋亡 (apoptosis)。
研究领域：Epigenetics | PI3K/Akt/mTOR | Apoptosis
In Vitro: Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells.
Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells.
Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only.
kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells.
kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism.
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