- 询价
- Cell Signaling Technology
- 3337
- USA
- 2026年05月29日
- W, IP
- Rabbit
- H,M
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- 文献和实验
- 技术资料
- 抗体英文名：
STING Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Leu325 of human STING protein
- 应用范围：
W, IP
- 宿主：
Rabbit
- 级别：
详见MSDS文件
- 库存：
大量
- 适应物种：
H,M
- 保质期：
详见说明书
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M | Endogenous | 35 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | STING Antibody recognizes endogenous levels of total STING protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu325 of human STING protein. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from 293T cells, mock transfected (-), transfected with a cDNA expression construct encoding human STING (hSTING; +), or transfected with a cDNA expression constructed encoding mouse STING (mSTING; +), using STING Antibody. Western Blotting
Western blot analysis of extracts from various cell lines using STING Antibody. |
| Background | STING (MITA/MYPS/TMEM173) is a recently identified adaptor found to be a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA (1, 2). It is ubiquitously expressed, resides in the ER, and has five transmembrane regions (1). Detection of cytoplasmic DNA by nucleic acid sensors such as DDX41 or IFI16 leads to their association with STING (3, 4). This causes STING, in a complex with TBK1, to traffic through the Golgi to perinuclear endosomes where TBK1 phosphorylates and activates IRFs and NF-κB, ultimately leading to induction of type I interferon and other genes important for the immune response. In addition, RIG-I, the cytoplasmic receptor for 5’ triphosphorylated viral RNA, was shown to associate with and require STING for induction of type I interferon (1). Finally, STING was recently demonstrated to be a direct sensor of cyclic dinucleotides produced by bacteria (5). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验广义的是从动物体射毒的针状构造的统称，而狭义的是膜翅目昆虫变形了的产卵管。由螫针的主体（stylet）、导沟、针鞘构成。从腹部内部的毒腺，把毒液注入敌对的动物体内。毒液的成分，蜜蜂的叫蜜蜂毒素（mellitin），主要成分是肽，但猎蜂使食饵动物麻痹的成分尚不明了。
Mol Cell：高福/尚桂军等团队合作揭示STING自抑制和内质网滞留的结构基础
导读 胞质中双链 DNA（dsDNA）能够被免疫系统识别，其主要传感器之一是环 GMP-AMP 合成酶（cGAS），它以 ATP 和 GTP 为底物合成 3', 2'-cGAMP。cGAMPs 作为第二信使激活干扰素基因刺激因子（STING），而作为一种内质网驻留蛋白，STING 在 cGAMP 刺激后由内质网向高尔基体转运，这被认为是信号转导的关键步骤。 活化的 STING 利用其 C 端尾部募集并激活 TANK-binding kinase 1（TBK1）和转录因子干扰素调节
Immunity：北大蒋争凡课题组发现 STING 后高尔基体囊泡转运的重要性及机制
cGAS-STING 通路是负责识别胞质 DNA 免疫应答的主要通路 1。cGAS 作为胞质 DNA 受体，可以被 DNA 和/或 Mn2+ 激活并利用 ATP 和 GTP 合成第二信使 2'3'-cGAMP，后者进一步激活 STING 并诱导 I 型干扰素等细胞因子的产生，从而介导抗病毒/肿瘤免疫反应。研究表明多种病原微生物入侵及各种压力胁迫，如氧化应激、代谢紊乱及 DNA 损伤等都可导致胞质 DNA 的累积及 Mn2+ 浓度的升高，从而激活 cGAS-STING 通路。因此，cGAS
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