- 询价
- Biological Industries
- SM-0001-0010
- 以色列
- 2026年01月09日
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- 详细信息
- 文献和实验
- 技术资料
- 细胞类型：
干细胞
- 供应商：
上海逍鹏生物科技有限公司
Product Description
Highly potent inhibitor of GSK3α and GSK3β.
CHIR99021 is a highly-potent and -selective inhibitor of GSK3α (IC50 of 10) and GSK3β (IC50 of 6.7), exhibiting over 500-fold selectivity when compared to its nearest homologs. CHIR99021 has been an effective component within differentiation protocols of pluripotent stem cells (PSCs) into human pancreatic beta cells (Pagliuca, et al.), neural progenitor cells (Li, et al. & Qi, et al.), cardiovascular progenitor cells (Cao, et al.), and functional cardiomyocytes (Lian, et al. & Burridge, et al.). Additionally, CHIR99021 has been shown to promote the induction of human PSCs (Li, W. et al.) and self-renewal of PSCS for maintenance purposes (Ying, et al.).
Product Synonyms:
CT 99021, CHIR-99021, CHIR 99021
Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.
产品官网链接：https://www.bioind.com/worldwide/chir-99021/
想了解更多种类的小分子，请点击官网：https://www.bioind.com/worldwide/products/stem-cell-research/small-molecules/
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文献和实验- - 1% 1% 1% 1% 1% 1% 1% 1% B27 - - - - - 0.5× 1× 1× 1× 1× N2 - - - - - 0.5× - - - - CHIR99021 - - 3 μM - - - - - - - Activin A - - 100 ng/ml 100 ng/ml 100 ng/ml
- NEAAs 1％ - - - - - - 2-mercaptoethanol 0.007‰ 0.007‰ 0.007‰ - - - - Y-27632 50 μM - - - - - - N2 - 1％ 1％ - - - - B27 - 2％ 2％ - - - - CHIR99021 - 12μM
1× - - - 1× insulin - - - - - - 19.4ng/ml - - - FGF basic/FGF-2 - 100ng/ml 5ng/ml - - - 100ng/ml - - - C046/C779 CHIR-99021 - - 1μM - - - - 7.5μM - - BMP
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