SB431542

Product Description
Highly-potent and -selective inhibitor of the TGF-β type I receptor, 10 mg
SB431542 is a highly-potent and -selective inhibitor of the TGF-β type I receptor, with specific inhibition of ALK5 (IC₅₀ of 94 nM) and its closest relatives ALK4 and ALK7 as part of the TGF-β/Activin/Nodal pathway. SB431542 has been shown to be a highly efficient additive for inducing neural differentiation of embryonic stem cells (ESCs) in a rapid manner when combined with Noggin (Chambers, et al.), or Noggin and LDN193189 (Cat. No. SM-0005-0010) (Edri, et al.), promoting the self-renewal of primitive neuroepithelia with hLIF and CHIR99021 (Cat. No. SM-0001-0010) (Li, et al. 2011), as well as the derivation of functional neurons from human pluripotent stem cells (PSCs) (Qi, et al.). Additionally, SB431542 allows for the enhanced differentiation of PSCs into cardiomyocytes (Kattman, et al.). 

Product Synonyms:

SB-431542, SB 431542
Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.