Qstatin,902688-24-8

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Qstatin

CAS No. : 902688-24-8

MCE 国际站：Qstatin

产品活性：QStatin 是一种有效且选择性的 SmcR 抑制剂 (V. harveyi LuxR 同源物)，EC₅₀ 值为 208.9 nM，与 SmcR 紧密结合并改变了蛋白质的柔韧性，从而改变了其转录调控活性。QStatin 在多种弧菌中显示 pan-QS 抑制剂活性，并减弱其在水生宿主中的毒力。QStatin 可用于水产养殖的可持续性抗弧菌病活性分子。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: QStatin (0.001 μM-10 μM; 5 hours) inhibits SmcR activity measured by the RLU level for V. vulnificusWT (pBB1), reveals EC₅₀ of 208.9 nM.
QStatin (5 μM-50 μM; 16 hours) reduces the activities of SmcR-activated virulence factors (protease and elastase) in V. vulnificus in a dose dependent manner.
QStatin (5 μM-50 μM; 16 hours) has no effect on the cellular levels of SmcR, indicating that QStatin does not affect the expression or stability of SmcR.

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