重组马IL-1RA北京品牌

特别提示：包括重组马IL-1RA在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组马IL-1RA
英文名称：Recombinant Equine Interleukin-1 Receptor Antagonist ( rEqIL-1RA)
产品货号：GS4909
产品规格：5μg

分子量：Approximately 17.4kDa,a single non-glycosylated polypeptide chain containing 152 amino acids.
储存条件：冷冻（-20℃）

概述

IL-1RA was initially called the IL-1 inhibitor which is encoded by the IL1RN gene and it is a member of the interleukin 1 cytokine family.It is secreted by various types of cells including immune cells,epithelial cells,and adipocytes.IL-1RA has functions of inhibiting the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling.IL-1RA is also used in the treatment of rheumatoid arthritis,an autoimmune disease in which IL-1 plays a key role.The equus caballus IL-1RA is a singlenon-glycosylated polypeptide chain containing 152 aminoacids and It has been shown to block the inflammatory responses induced by IL-1bothinvitroandinvivo.Theproteinshows26%amino acid homology to IL-1β and 19%homology to IL-1α.It also shares 78%~80%a.a.sequence identity with murine,rat,porcine IL-1RA.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze- dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 3.0μg/ml,corresponding to a specific activity of>333 IU/mg in the presence of 50pg/ml rHuIL-1α.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rEqIL-1RA as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VAGYLQESNT KLQEKIDVVP IEPDALFLGL HGRKLCLACV KSGDEIRFQL EAVNITDLSK NKEENKRFTF IRSNSGPTTS FESAACPGWF LCTAQEADRP VSLTNKPKES FMVTKFYLQE DQ

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