Tocris货号2634-10mg与50mg现货DAPT上海

Tocris货号2634-10mg现货DAPT上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

Tocris货号2634-50mg现货DAPT上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

Chemical Name:(2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester

Purity:≥99%

Biological Activity

DAPT is a γ-secretase inhibitor. DAPT reduces Aβ40 and Aβ42 levels in human primary neuronal cultures (IC₅₀ values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. DAPT has no effect on APPα and APPβ levels. DAPT blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) and causes ESCs to commit to neuronal differentiation. DAPT can be used in a small molecule cocktail to derive cortical and dopaminergic neurons from hPSCs (see our protocols below). Used in protocols to generate myoblasts from human human iPSCs. DAPT also promotes the formation of cone photoreceptors in retinal organoids.

For more information about how DAPT may be used, see our protocols: Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts, Generating Midbrain Dopaminergic Neurons from hPSCs.

DAPT synthesized to Ancillary Material Grade also available.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

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Citations for DAPT(部分:文献)