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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 生长状态：
悬浮生长
- 物种来源：
人
- 是否是肿瘤细胞：
1
- 库存：
大量
- 细胞类型：
B淋巴细胞
- 器官来源：
外周血
- 相关疾病：
其他疾病
- ATCC Number：
TIB-196™
- 年限：
53 years adult
- 免疫类型：
IgE; lambda light chain
- 细胞形态：
淋巴样
- 运输方式：
冻存运输
| Designations: | U266B1 [U266] | ||
| Depositors: | NK Nilsson | ||
| Isotype: | IgE; lambda light chain | ||
| Biosafety Level: | 1 | ||
| Shipped: | frozen | ||
| Medium & Serum: | See Propagation | ||
| Growth Properties: | suspension | ||
| Organism: | Homo sapiens | ||
| Morphology: | lymphoblast |
||
| Source: | Organ: peripheral blood Disease: myeloma; plasmacytoma Cell Type: B lymphocyte; |
||
| Cellular Products: | immunoglobulin; monoclonal antibody; interleukin 6 (interleukin-6, IL-6) | ||
| Permits/Forms: | In addition to the MTA mentioned above, other ATCC and/or regulatory permits may be required for the transfer of this ATCC material. Anyone purchasing ATCC material is ultimately responsible for obtaining the permits. Please click here for information regarding the specific requirements for shipment to your location. | ||
| Applications: | transfection host | ||
| DNA Profile (STR): | Amelogenin: X,Y CSF1PO: 12,13 D13S317: 12 D16S539: 10 D5S818: 11,12 D7S820: 11,12 THO1: 5,7 TPOX: 8 vWA: 17 |
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| Age: | 53 years adult | ||
| Gender: | male | ||
| Comments: | U266 cells have been reported to produce human IL-6. | ||
| Propagation: | ATCC complete growth medium: The base medium for this cell line is ATCC-formulated RPMI-1640 Medium, Catalog No. 30-2001. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 15%. |
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| Subculturing: | Medium Renewal: Every 2 to 3 days Cultures can be maintained by addition or replacement of fresh medium. Start cultures at 3 x 10 exp5 cells/ml and maintain between 1 x 10 exp5 and 1 x 10 exp6 cells/ml. |
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| Preservation: | culture medium 95%; DMSO, 5% | ||
| Related Products: | Recommended medium (without the additional supplements or serum described under ATCC Medium):ATCC 30-2001 recommended serum:ATCC 30-2020 |
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| References: | 1180: Nilsson K, et al. Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient. Clin. Exp. Immunol. 7: 477-489, 1970. PubMed: 4097745 22377: Kawano M, et al. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332: 83-85, 1988. PubMed: 3258060 32396: Kolanus W, et al. alphaLbeta2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1 a cytoplasmic regulatory molecule. Cell 86: 233-242, 1996. PubMed: 8706128 |
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文献和实验B是 Backcross，即回交之意，而 B1 则为表示回交第一代的记号。
B1 细胞 B1细胞为CD5+B细胞，所介导的免疫应答特点为：不发生体细胞突变，无亲和力成熟，仅产生低亲和力的IgM抗体，不产生记忆细胞。 1．产生天然IgM 天然IgM是预成抗体的主要成分，主要由D1细胞分泌。这种抗体是多反应性的，能与许多病原体相关糖类抗原结合。如前所述，天然抗体可以看作是一种模式识别分子，产生机制尚未完全阐明，估计和机体在个体发育中遭受过病原体感染有关。天然抗体能保护机体防御细菌(如肺炎链球菌)感染
【进展|热点】Nature Review Immunology: 掀起B1细胞的「红盖头」
揭开B1细胞的神秘面纱——深入了解B1细胞 文章出处：The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol. 2011. 11:34-46 主要内容： 不像对于T细胞我们研究和认识得较多，对于B细胞我们研究和认识得都较少。B细胞主要可以分为B1细胞和B2细胞，B1细胞根据是否表达CD5又可以进一步分为B1-a细胞
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