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- 器官来源：
卵巢
- 物种来源：
人
- 是否是肿瘤细胞：
0
- 相关疾病：
其他疾病
- ATCC Number：
CRL-3128™
- 运输方式：
冻存运输
- 库存：
大量
- 细胞形态：
上皮样
- 年限：
78 years
- 生长状态：
贴壁生长
| Designations: | UACC-1598 | ||
| Depositors: | K Brown | ||
| Biosafety Level: | 1 | ||
| Shipped: | frozen | ||
| Medium & Serum: | See Propagation | ||
| Growth Properties: | adherent | ||
| Organism: | Homo sapiens | ||
| Morphology: | epithelial-like |
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| Source: | Organ: ovary Disease: cystadenocarcinoma Tumor Stage: Grade IV |
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| Cellular Products: | cytokeratin (MAK-6), not expressed progesterone, not expressed |
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| Permits/Forms: | In addition to the MTA mentioned above, other ATCC and/or regulatory permits may be required for the transfer of this ATCC material. Anyone purchasing ATCC material is ultimately responsible for obtaining the permits. Please click here for information regarding the specific requirements for shipment to your location. | ||
| Isolation: | Isolation date: January 1989 | ||
| Applications: | Pathology confirmed that the specimen was a grade IV poorly differentiated papillary serous cystadenocarcinoma. The human ovarian cancer cell line, UACC-1598, was derived from the right ovary of an untreated 78-year-old female. The UACC-1598 cell line expresses the N-myc oncogene, which is rarely amplified in ovarian cancers. UACC-1598 cells express low levels of Epidermal Growth Factor Receptor erbB2, and are negative for ras by ELISA assay. A high copy number amplification of eukaryotic translation initiation factor 5A2 (eIF-5A2) oncogene was detected in this region. |
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| Receptors: | Epidermal Growth Factor Receptor (EGFR), low expression | ||
| Oncogene: | N-myc, positive; eukaryotic translation initiation factor 5A2 (eIF-5A2 ), positive; c-erbB2, low expression; ras , negative | ||
| DNA Profile (STR): | CSF1PO: 10 D13S317: 13 D16S539: 11, 12 D5S818: 13 D7S820: 7, 9 THO1: 7, 9.3 TPOX: 8, 11 vWA: 14 Amelogenin: X |
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| Age: | 78 years | ||
| Gender: | female | ||
| Comments: | The human ovarian cancer cell line, UACC-1598, was derived from the right ovary of an untreated 78-year-old female. Pathology confirmed that the specimen was a grade IV poorly differentiated papillary serous cystadenocarcinoma. The UACC-1598 cell line expresses the N-myc oncogene, which is rarely amplified in ovarian cancers. UACC-1598 cells express low levels of Epidermal Growth Factor Receptor erbB2, and are negative for ras by ELISA assay. The UACC-1598 cell line contains high-level amplification at 3q26 in the form of double minute chromosomes. A high copy number amplification of eukaryotic translation initiation factor 5A2 (eIF-5A2 ) oncogene was detected in this region. Overexpression the eIF-5A2 oncogene may play an important role in ovarian cancer pathogenesis. [16173601 ] |
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| Propagation: | ATCC complete growth medium: The base medium for this cell line is ATCC-formulated Leibovitz's L-15 Medium, Catalog No. 30-2008. To make the complete growth medium, add the following components to the base medium:
Note: Do not filter complete medium. Temperature: 37.0°C Atmosphere: air, 100% Growth Conditions: These cells grow very slowly. |
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| Subculturing: | Protocol: Subculture when cells reach 80% to 90% confluence. These cells pile up and slough off the flask surface if they become over-confluent. Volumes used in this protocol are for 75 cm2 flasks; proportionally reduce or increase amount of dissociation medium for culture vessels of other sizes.
Subcultivation ratio: A subcultivation ratio of 1:2 is recommended. Medium renewal: every 5 to 7 days |
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| Preservation: | Freeze medium: complete growth medium supplemented with an additional 10% fetal bovine serum (FBS) and 10% (v/v) DMSO Storage temperature: liquid nitrogen vapor phase |
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| Related Products: | Recommended medium (without the additional serum described under ATCC Medium): ATCC 30-2008 Recommended serum: ATCC 30-2020 Cell culture tested DMSO: ATCC 4-X 0.25% (w/v) Trypsin - 0.53mM EDTA in Hank's BSS (w/o Ca++, Mg ++): ATCC 30-2101 Phosphate-buffered saline: ATCC 30-2200 L-Glutamine solution, 200mM: ATCC 30-2214 Erythrosin B vital stain solution: ATCC 30-2404 |
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| References: | 16173530: Heiskanen MA, et al. Detection of gene amplification by genomic hybridization to cDNA microarrays. Cancer Res. 60(4): 799-802, 2000. PubMed: 10706083 16173531: Guan XY, et al. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. Cancer Res. 61(9): 3806-3809, 2001. PubMed: 11325856 16173601: Guan XY, et al. Oncogenic role of eIF-5A2 in the development of ovarian cancer. Cancer Research 64 (12): 4197-4200, 2004. PubMed: 15205331 16174065: Clement P, et al. Identification and characterization of eukaryotic initiation factor 5A-2. Eur. J. Biochem. 147(21): 4254-4263, 2003. PubMed: 14622290 16174066: Clement P, et al. Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. FEBS J. 273(6): 1102-1114: 2006. PubMed: 16519677 |
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