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- 文献和实验
- 技术资料
- 库存:
大量
- 免疫类型:
IgG1
- 细胞形态:
淋巴样
- 生长状态:
悬浮生长
- ATCC Number:
HB-258™
- 运输方式:
冻存运输
- 物种来源:
小鼠
- 是否是肿瘤细胞:
0
| Designations: | FW11-24-17-36 | ||
| Depositors: | CR Mackay | ||
| Isotype: | IgG1 | ||
| Biosafety Level: | 1 | ||
| Shipped: | frozen | ||
| Medium & Serum: | See Propagation | ||
| Growth Properties: | suspension | ||
| Organism: | Mus musculus (B cell); Mus musculus (myeloma) deposited as mouse (B cell); mouse (myeloma) | ||
| Morphology: | lymphoblast |
||
| Source: | Cell Type: hybridoma: B lymphocyte; | ||
| Cellular Products: | immunoglobulin; monoclonal antibody; against the v9 variant of human CD44 | ||
| Permits/Forms: | In addition to the MTA mentioned above, other ATCC and/or regulatory permits may be required for the transfer of this ATCC material. Anyone purchasing ATCC material is ultimately responsible for obtaining the permits. Please click here for information regarding the specific requirements for shipment to your location. | ||
| Comments: | Animals were immunized with a fusion protein corresponding to the variant region of human CD44 (exons 3v to 10v). Spleen cells were fused with Sp2/0-Ag14 myeloma cells. The antibody is specific for the product of the 9v exon. |
||
| Propagation: | ATCC complete growth medium: Iscove's modified Dulbecco's medium with 2 mM L-glutamine, 90%; fetal bovine serum, 10% |
||
| Subculturing: | Medium Renewal: Every 2 to 3 days Cultures can be maintained by addition or replacement of fresh medium. Start cultures at 2 X 10 exp5 cells/ml and maintain between 1 X 10 exp5 and 1 X 10 exp6 cells/ml. |
||
| Preservation: | Culture medium, 95%; DMSO, 5% | ||
| References: | 22355: Mackay CR, et al. Expression and modulation of CD44 variant isoforms in humans. J. Cell Biol. 124: 71-82, 1994. PubMed: 7507492 | ||
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文献和实验3.82 3.47 3.25 3.09 2.97 2.87 2.80 2.73 2.64 2.53 2.42 2.31 2.18 2.04 21 22 4.38 3.73 3.44 3.21 3.05 2.93 2.84 2.76 2.70 2.60 2.50 2.39 2.27 2.14 2.00 22 23 4.35 3.75 3.41 3.18 3.02 2.90 2.81 2.73 2.67 2.57 2.47 2.36 2.24 2.11 1.97 23 24
恢复 80% 头发生长!首个治疗斑秃的口服脱发新药在中国获批上市
% 的患者实现了超过 80% 的头皮毛发覆盖,11~13% 的患者实现了超过 90% 的头皮毛发覆盖; 接受 4 mg/天巴瑞替尼治疗的患者中有 32~35% 的患者实现了超过 80% 的头皮毛发覆盖,24~26% 的患者实现了超过 90% 的头皮毛发覆盖; 安慰剂受试组的比例分别为 3~5% 及 1~4%。 此外,在使用巴瑞替尼治疗 36 周后,患者的眉毛和睫毛的覆盖率都有所改善,而这些患者在基线时均有明显的眉毛或睫毛脱落。
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