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- Invitrogen
- A33502
- 2025年07月07日
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- 详细信息
- 技术资料
EGFR (ErbB1) T790M C797S L858R Recombinant Human Protein
货号： A33502
| 货号 | 规格 | |||
|---|---|---|---|---|
| A33502 | 10 µg | |||
| A33556 | 100 µg | |||
| A33725 | 1 mg |
规格
| Accession Number: | NP_005219.2 |
|---|---|
| Molecular Weight: | 84.2 kDa |
| Product Size: | 10 µg |
| Protein Length or Portion (a.a.): | aa 695 - end |
| Protein Tag or Fusion: | GST Tag |
| Validated Application: | Kinase Assay |
| Expression: | Insect |
| Kinase Family: | EGF Receptors (ErbBs) |
| Protein Form: | Active, Cytoplasmic, Mutant, Recombinant |
| Shipping Condition: | Dry Ice |
内容及储存
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol
描述
This EGFR (ErbB1) T790M C797S L858R recombinant human protein (695–end) was expressed in insect cells. EGFR receptor tyrosine kinase is a transmembrane glycoprotein. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. EGFR (ErbB1) T790M C797S L858R recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
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