- 询价
- InvivoGen
- France
- tlrl-2395-1
- 2025年07月09日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保质期：
/
- 英文名：
ODN 2395
- 库存：
大量
- 供应商：
Neobioscience
- CAS号：
/
- 保存条件：
-20
- 规格：
1 mg
货号：tlrl-2395-1
规格：1 mg
产品描述：
CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs)1 . These CpG motifs are present at a 20-fold greater frequency in bacterial DNA compared to mammalian DNA. CpG ODNs are recognized by Toll-like receptor 9 (TLR9) leading to strong immunostimulatory effects2 . Three classes of stimulatory CpG ODNs have been identified, classes A, B and C, which differ in their immunostimulatory activities3-4. Class A CpG ODNs are characterized by a phosphodiester central CpG-containing palindromic motif and a phosphorothioate 3’ poly-G string. They induce high IFN-a production from plasmacytoid dendritic cells (pDC) but are weak stimulators of TLR9-dependent NF-kB signaling. Class B CpG ODNs contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-a secretion. Class C CpG ODNs combine features of both classes A and B. They contain a complete phosphorothioate backbone and a CpGcontaining palindromic motif. Class C CpG ODNs induce strong IFN-a production from pDC and B cell stimulation. ODN 2395 is a Class C CpG ODN with a preference for human and murine TLR9.
http://www.invivogen.com/odn2395b
详情请咨询Invivogen一级代理商-欣博盛生物科技
全国服务热线: 4006-800-892 邮箱: market@neobioscience.com
深圳: 0755-26755892 北京: 010-88594029 上海: 021-34613729
广州：18024516375 香港: 852-69410778
代理品牌网站: www.neobioscience.com
自主品牌网站: www.neobioscience.net
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Antisense Efficacy: Site-Restricted In Vivo and Ex Vivo Models
In the laboratory, antisense oligodeoxynucleotides (ODN) have repeatedly demonstrated efficacy in modulating the expression of various genes, thus providing important insights into their roles in tumorigenesis or normal growth and development
Modulation of human interferon- biosynthesis by antisense oligodeoxynucleotides
We investigated the inhibition of human interferon-γ (HuIFN-γ) production in cultures of lymphocytes with the use of the antisense strategy. Out of a series of antisense oligodeoxynucleotides (ODN) complementary to different regions of the HuIFN
Transport of Antisense Across the Blood-Brain Barrier
. Recently, two types of unmodified antisense analogs have been shown to effectively cross the BBB and affect CNS function. One of the analogs, a phosphorothioate oligodeoxy-nucleotide (P-ODN) directed against the amyloid β protein, was peripherally
技术资料暂无技术资料 索取技术资料
