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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3190.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1300.0 |
| 规格： | 5 mg | 产品价格： | ￥2900.0 |
| 规格： | 10 mg | 产品价格： | ￥4550.0 |
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BI8622
CAS No. : 1875036-74-0
MCE 国际站：BI8622
产品活性：BI8622 是一种泛素连接酶 HUWE1 特异性拮抗剂，IC50 为 3.1 μM。
研究领域：Metabolic Enzyme/Protease
作用靶点：E1/E2/E3 Enzyme
In Vitro: BI8622 induces HUWE1 ectopically expresses to abolish ubiquitination of MCL1 with an IC50 value of 6.8 μM in HeLa cells.
BI8622 suppresses colony formation of Ls174T cells with estimated IC50 value of 8.4 μM.
BI8622 (10 μM; 1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1.
BI8622 (0-50 μM; 16 hours) retards the degradation of MCL1 in response to UV irradiation by inhibiting HUWE1 in HeLa cells.
BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells.
相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Oxygen Sensing Compound Library | Ubiquitination Compound Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | TAK-243 | Nutlin-3a | Subasumstat | Idasanutlin | Navtemadlin | ML-792 | Mezigdomide | PYR-41 | MD-224 | 2-D08 | Siremadlin | Cbl-b-IN-1 | RG7112 | C25-140 | Ginkgolic Acid | Milademetan | Indole-3-carbinol | HOIPIN-8 | LS-102 | PRT4165 | RB-3 | Alrizomadlin | Avadomide | NSC232003 | BI8626 | NSC697923 | Heclin | SZL P1-41 | NVP-CGM097
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文献和实验to 65o C for 10 minutes (2) Ethanol precipitation (a) add together: labelling mix (from 1.d) - 50µl 147µl ddH2 O 74µl 4M NaCl 2µl salmon sperm DNA (10µg/µl stock) 467µl cold (-20o C) ethanol (b) keep at 4o C
for 3 hours (d) stop reaction by heating to 65o C for 10 minutes (2) Ethanol precipitation (a) add together: labelling mix (from 1.d) - 50µl 147µl ddH2 O 74µl 4M NaCl 2µl salmon sperm DNA (10µg/µl stock) 467µl cold
and Quaternary Structure / 65 3.7 Cofactors in Enzymes / 68 3.8 Summary / 71 References and Further Reading / 74 4 Protein‒Ligand Binding Equilibria 76 4.1 The Equilibrium Dissociation Constant, K / 76 4.2 The Kinetic Approach to Equilibrium / 78
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