Jaceosidin棕矢车菊素,18085-97-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Jaceosidin

CAS No. : 18085-97-7

MCE 国际站：Jaceosidin

产品活性：Jaceosidin 是从 Artemisia vestita 中得到的黄酮类化合物，可激活 Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。Jaceosidin 具有抗癌和抗炎作用，能够降低炎性因子水平，激活 NF-κB，抑制 COX-2 的表达。

研究领域：Apoptosis  |  Immunology/Inflammation

作用靶点：Bcl-2 Family  |  COX  |  Apoptosis

In Vitro: Jaceosidin (30, 50, 75 μM) induces apoptosis in human renal carcinoma Caki cells after treatment for 24 h, shows no obvious effect on normal cells.
?Jaceosidin (75 μM) reduces MMP levels and causes cytochrome c release into the cytoplasm through Bax activation.
?Jaceosidin-mediated apoptosis is involved in downregulation of Mcl-1, c-FLIP expression, which is via inhibition of NF-κB and/or Sp1 transcriptional activity.
?Jaceosidin shows cytostatic activity to HES and HESC cells with IC₅₀s of 52.68 and 55.10 μM, and is less cytotocxic on Hec1 A and KLE (IC₅₀, 70.54, 147.14 μM, respectively), after treatment for 48 h.

In Vivo: Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice.
?Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice.
?Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  NF-κB Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Lipid Compound Library  |  Phenols Library  |  Pyroptosis Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Flavonoids Library  |  Anti-Pancreatic Cancer Compound Library  |  Mitochondria-Targeted Compound Library  |  Food-Sourced Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Cancer Natural Product Library  |  Antidepressant Compound Library  |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Anti-Prostate Cancer Compound Library  |  Cell Death Library  |  MG-132  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  LY294002  |  Tamoxifen  |  Paclitaxel  |  Y-27632  |  Acetylcysteine  |  Angiotensin II human  |  2-Deoxy-D-glucose  |  Staurosporine  |  Venetoclax  |  SB-431542  |  Actinomycin D  |  Deferoxamine mesylate  |  Bortezomib  |  5-Fluorouracil  |  Trametinib  |  Sorafenib  |  Oxaliplatin  |  Gemcitabine  |  Temozolomide  |  Rotenone  |  Mdivi-1  |  Elesclomol  |  Ruxolitinib  |  Decitabine  |  Navitoclax  |  SP600125  |  MK-2206 dihydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds