TPPB

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TPPB

CAS No. : 497259-23-1

MCE 国际站：TPPB

产品活性：TPPB是苯并内酰胺衍生的可渗透细胞的蛋白激酶C (PKC) 活化物，K_i 值为11.9 nM。

研究领域：Epigenetics  |  TGF-beta/Smad

作用靶点：PKC

In Vitro: By use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB (Compound 5e). TPPB has a role against Aβ_25-35-induced neurotoxicity in PC12 cells. TPPB at concentration of 1 μM could antagonize Aβ_25-35 induced cell damage. TPPB could increase the phosphorylation of Akt, PKC, MARCKS and MAPK, which are inhibited by Aβ_25-35 treatment. TPPB inhibits the activation of caspase-3 induced by Aβ_25-35.

In Vivo: TPPB is evaluated for induction of hyperplasia after topical application to the shaved backs of outbred Sencar mice and shows a modest response at 300 μg.

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