Nec-4,1041644-43-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Nec-4

CAS No. : 1041644-43-2

MCE 国际站：Nec-4

产品活性：Nec-4, 一个三环衍生物，是受体相互作用蛋白 1 (RIP1) 的一个有效抑制剂，其 IC₅₀ 值为 2.6 μM，K_i 值为 0.46 μM。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: Nec-4 (compound 9) is a slightly better competitor than 7 with a lower K_i value that is similar to R-3. Nec-4 is again a slightly better competitor than Rac-3 with K_i and IC₅₀ values comparable to 7 (Nec-4: IC₅₀=2.6±0.1 μM, K_i=0.46±0.05 μM; 7: IC₅₀=10.7±1.8 μM, K_i=4.5±0.9 μM). Overall, all three compounds cross-compete with each other but Nec-4 is able to more effectively displace both 20 and 26 in comparison to the parent compounds Rac-3 and 7, respectively. This suggests that Nec-4 binding likely significantly overlaps with both the Nec-1 and the Nec-3 binding sites.

相关产品：Necrostatin-1  |  GSK-872  |  Necrostatin 2 racemate  |  GSK2982772  |  GSK583  |  GSK-843  |  GSK840  |  GSK547  |  RIPA-56  |  RIP1/RIP3/MLKL activator 1  |  WEHI-345  |  GSK2983559  |  PROTAC RIPK degrader-2  |  Apostatin-1  |  GSK3145095  |  HS-1371  |  GSK2593074A  |  GSK963  |  PROTAC RIPK degrader-6  |  RIPK3-IN-1  |  Eclitasertib  |  ICCB-19 hydrochloride  |  OD36  |  GSK481  |  PK68  |  RIP1 kinase inhibitor 1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds