Aurantio-obtusin橙黄决明素,67979-25

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Aurantio-obtusin

CAS No. : 67979-25-3

MCE 国际站：Aurantio-obtusin

产品活性：Aurantio-obtusin 是一种可以从决明子中提取的蒽醌类化合物。Aurantio-obtusin 具有降血压、降血脂和抗炎的作用。Aurantio-obtusin 是一种口服有效的血管扩张剂。Aurantio-obtusin 通过 AMPK/自噬和 AMPK/TFEB 介导的脂质积累抑制的途径来改善肝脂肪 变性。

研究领域：Apoptosis  |  Immunology/Inflammation

作用靶点：TNF Receptor  |  COX

In Vitro: Aurantio-obtusin (6.25-100 μM; 24 h) significantly decreases the production of NO and PGE2, and inhibits the expression of IL-6, TNF-α, COX-2 protein in RAW264.7 cells treated with LPS (0.2µg/mL).
Aurantio-obtusin (6.25-100 μM; 12 h) inhibits the activation of NF-κ B by inhibiting the phosphorylation of i-κB and IKK in RAW264.7 cells treated with LPS (0.2µg/mL).
Aurantioobtusin (1-10000 nM) induces small resistance vasodilation in rat MA in a concentration-dependent manner.

In Vivo: Aurantio-obtusin (5-15 mg/kg; Oral administration; Single dose) in HFSW-induced mice reduces HFSW-induced lipid droplet accumulation and extensive steatosis in a dose-dependent manner.
Aurantio-obtusin (5-15 mg/kg; Oral administration; A single dose) inhibits fatty acid synthesis, promotes FAO and activates AMPK signaling and autophagy in HFSW-induced mice .

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