Autophinib,1644443-47-9

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Autophinib

CAS No. : 1644443-47-9

MCE 国际站：Autophinib

产品活性：Autophinib 是一种有效的，选择性细胞自噬抑制剂，对于饥饿和 Rapamycin 诱导的自噬，IC₅₀ 值分别为 90 nM 和 40 nM。Autophinib 还是一种 ATP 竞争性的 VPS34 抑制剂，其 IC₅₀ 值为 19 nM。Autophinib 通过靶向 VPS34 来抑制饥饿或 Rapamycin 诱导的细胞自噬。

研究领域：Autophagy  |  PI3K/Akt/mTOR

作用靶点：Autophagy  |  PI3K

In Vitro: Autophinib (0.01-1 μM) inhibits LC3 lipidation to form LC3-II in a dose-dependent manner in starved MCF7-LC3 cells. Consistent with inhibition of autophagic flux, Autophinib also inhibits p62 degradation by autophagy dose-dependently in MCF7-LC3 cells.
Autophinib enhances cell death (EC₅₀ of 264 nM) of starved cells as compared to fed cells, which occurred via the induction of apoptosis (EC₅₀ of 234 nM) in MCF7 cells.

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