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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
PF-04965842
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1622902-68-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1650.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2165.0 |
| 规格： | 25 mg | 产品价格： | ￥3900.0 |
| 规格： | 50 mg | 产品价格： | ￥5655.0 |
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Abrocitinib
CAS No. : 1622902-68-4
MCE 国际站：Abrocitinib
产品活性：Abrocitinib (PF-04965842) 是一种有效、可口服、选择性的 JAK1 抑制剂，对 JAK1 和 JAK2 的 IC50 值分别为 29 和 803 nM。Abrocitinib (PF-04965842) 可抑制 TYK2 的活性(IC50，1.253 μM) 和刺激后 STAT1，STAT3 和 STAT5 的磷酸化水平。可用于自身免疫症的研究。
研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt
作用靶点：JAK
In Vitro: Abrocitinib (Compound 25) inhibits IFNα-stimulated phosphorylation of STAT3, IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 189, 163 nM, 7.178 μM, respectively.
In Vivo: Abrocitinib (Compound 25; 5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling in rat adjuvant-induced arthritis model.
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