P11149,164724-79-2

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P11149

CAS No. : 164724-79-2

MCE 国际站：P11149

产品活性：P11149 是 Galanthamine 的一个衍生物，是有效的、竞争性的、弱透过血脑屏障的、口服活性的、选择性的 AChE 抑制剂，具有中枢胆碱能活性和安全性。P11149 抑制大鼠 BChE/AChE 的 IC₅₀ 值为 1.3 μM。P11149 用于阿尔兹海默症的研究。

研究领域：Neuronal Signaling

作用靶点：Cholinesterase (ChE)

In Vivo: P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG.
P11149 exhibits greater s.c. bioavailability than p.o. .
Oral P11149 in mice produces Sal, Lac and tremors at doses similar to those in rats, whereas 6-DMG, P1 1012 and GAL produces Sal and Lac at doses lower than those in rats.
P11149 exhibits T_1/2(el) of 2.4 h and C_max of 585 ng/mL in rat plasma.

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