GNE 220,1199590-75-4

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GNE 220

CAS No. : 1199590-75-4

MCE 国际站：GNE 220

产品活性：GNE-220 是一种有效的选择性 MAP4K4 抑制剂，IC₅₀ 为 7 nM。

研究领域：MAPK/ERK Pathway

作用靶点：MAP4K

In Vitro: GNE-220 also inhibits a few other kinases with IC₅₀s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM⁺ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1⁺ long focal adhesions (FAs).

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