- ￥1350 - 3000
- Proteintech
- 18309-1-AP
- 2025年10月13日
- WB, IP, ELISA
- Rabbit
- human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
None
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, IP, ELISA
- 靶点：
CD61 / Integrin beta 3
- 抗体英文名：
CD61 / Integrin beta 3 Polyclonal antibody
- 抗体名：
CD61 / Integrin beta 3 Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | Human peripheral blood platelets, mouse spleen tissue, rat spleen tissue |
| Positive IP detected in | mouse spleen tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:4000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
18309-1-AP targets CD61 / Integrin beta 3 in WB, IHC, IF, IP, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IP, ELISA |
| 文献引用应用 | WB, IHC, IF, IP, CoIP |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, rat, hamster |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| 别名 | CD61, GP3A, GPIIIa, Integrin beta 3, Integrin beta-3, ITGB3 |
| 计算分子量 | 87 kDa |
| 观测分子量 | 100 kDa |
| GenBank蛋白编号 | BC127667 |
| 基因名称 | Integrin beta 3 |
| Gene ID (NCBI) | 3690 |
| RRID | AB_2128759 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P05106 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Integrin beta-3, also named as CD61 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin beta-3 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Human integrin beta-3 has a calculated molecular weight of 87 kDa. As a result of glycosylation, the apparent molecular mass of integrin beta-3 is approximately 90-110 kDa.
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文献和实验| Species | Application | Title |
|---|---|---|
| human | WB | Sci Adv Platelet-derived porous nanomotor for thrombus therapy.Authors - Mimi Wan |
| mouse | WB | Theranostics Platelets camouflaged nanovehicle improved bladder cancer immunotherapy by triggering pyroptosisAuthors - Jiale Tian |
| WB | Nat Commun Targeting Gα13-integrin interaction ameliorates systemic inflammation.Authors - Ni Cheng | |
| human,mouse | IF | Biomaterials Construction and evaluation of novel αvβ3 integrin ligand-conjugated ultrasmall star polymer micelles targeted glomerular podocytes through GFB permeation.Authors - Chengyuan Huang |
| rat | WB | Theranostics A blood circulation-prolonging peptide anchored biomimetic phage-platelet hybrid nanoparticle system for prolonged blood circulation and optimized anti-bacterial performance.Authors - Peipei Jin |
Thromb Res Repurposing of rilpivirine for preventing platelet β3 integrin-dependent thrombosis by targeting c-Src active autophosphorylationAuthors - Kui Liu |
10X TBS：24.2 g Trisbase, 80 g NaCl；用1N HCl调pH为 7.6 7. 甲醇 8. TBS/T缓冲液：1X TBS, 0.1% Tween-20 9. 封闭缓冲液(TBS/T)：1X TBS,0.1% Tween-20加5% w/v脱脂奶粉或BSA 10. 一抗的稀释：1X TBS,0.1% Tween-20 加 5% BSA ( 多抗) 或 5%脱脂奶粉( 单抗)。Note： 一般来说，BSA被推荐用于多克隆抗体
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
phosphatase 2 (formerly 2A), catalytic subunit, beta isoform (PPP2CB), mRNA 1195 NM_004910 Homo sapiens phosphatidylinositol transfer protein, membrane-associated (PITPNM), mRNA 869 NM_004517 Homo sapiens integrin-linked kinase (ILK), mRNA 654 NM
10X TBS：24.2 g Trisbase, 80 g NaCl;用1N HCl调pH为 7.6 7. 甲醇 8. TBS/T缓冲液：1X TBS, 0.1% Tween-20 9. 封闭缓冲液(TBS/T)：1X TBS,0.1% Tween-20加5% w/v脱脂奶粉或BSA 10. 一抗的稀释：1X TBS,0.1% Tween-20 加 5% BSA ( 多抗) 或 5%脱脂奶粉( 单抗)。Note： 一般来说，BSA被推荐用于多克隆抗体
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