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- 百奥莱博
- M00732-KRX
- 北京
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
166
- 英文名：
ZM-447439
- CAS号：
331771-20-1
- 保质期：
2年
- 供应商：
北京百奥莱博科技有限公司
- 保存条件：
-20℃，有效期2年，溶入溶剂后-20℃
- 规格：
1mL(10mM)|5mg|10mg|50mg
特别提示：包括Aurora A和Aurora B抑制剂(ZM447439)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
产品名称：Aurora A和Aurora B抑制剂(ZM447439)
英文名称：ZM-447439
产品货号：M00732
产品规格：1mL(10mM)|5mg|10mg|50mg
ZM447439是ATP竞争性Aurora A和B选择性抑制剂，IC50分别为110nM和130nM。
注：本品仅可用于科研实验，严禁用于临床医疗及其他用途！
CAS号：331771-20-1
纯度：98.88%
分子式：C₂₉H₃₁N₅O₄
分子量：513.59
结构式：
储存条件：-20℃，有效期2年，溶入溶剂后-20℃请尽量在一个月内使用。
除了Aurora A和Aurora B抑制剂(ZM447439),，我公司还供应以下相关产品：
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M00484 (USP7抑制剂(P005091) 1mL(10mM)|5mg|10mg|50mg|100mg
M00613 Epigenetic Reader Domain抑制剂 1mL(10mM)|2mg|5mg|10mg|50mg|100mg
M01711 组蛋白去甲基化酶抑制剂（KDM5A-IN-1） 1mL(10mM)|1mg|5mg|10mg|50mg|100mg
M01930 VE-cadherin抑制剂（Lycorine hydrochloride） 1mL(10mM)|10mg|25mg|50mg|100mg
M01986 ADP-核糖基化因子1的GTP酶活化蛋白抑制剂(QS11) 1mL(10mM)|5mg|10mg|25mg|50mg|100mg
M02140 PDK1抑制剂(BX-912) 1mL(10mM)|5mg|50mg|100mg
M02241 DprE1抑制剂(DprE1-IN-2) 1mL(10mM)|2mg|5mg|10mg|50mg|100mg
M04342 SIK抑制剂(HG-9-91-01) 1mL(10mM)|2mg|5mg|10mg|50mg|100mg
M04583 COX-2抑制剂(Etoricoxib) 1mL(10mM)|10mg|50mg|100mg
M04822 糜酶chymase抑制剂 1mL(10mM)|2mg|5mg|10mg|50mg
M05237 SGLT-2抑制剂(Empagliflozin) 1mL(10mM)|5mg|10mg|50mg|100mg
M05248 SGK1抑制剂(EMD638683) 1mL(10mM)|5mg|10mg|50mg|100mg
M07287 α1肾*腺素受体激动剂 1mL(10mM)|100mg
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文献和实验The Ipl1/Aurora Kinase Family: Methods of Inhibition and Functional Analysis in Mammalian Cells
-molecule inhibitor ZM447439, RNA interference, and overexpression of a catalytic mutant. All of these methods have proved useful in studying Aurora B as well as validating it as a potential anticancer drug target. However, while all three methods are useful
A method for analyzing the ubiquitination and degradation of aurora-A
has been well characterized and it was shown that it is ubiquitin proteasome pathway that leads to the elimination of cyclins. By now, many other regulatory proteins were shown to be degraded by the same pathway, among them members of the aurora kinase family, degraded
Studying the Roles of Aurora-C Kinase During Meiosis in Mouse Oocytes
We previously isolated Aurora-C (Aurkc/Aie1 ) in a screen for kinases expressed in mouse sperm and eggs. Aurora-C kinase was reported to be a chromosomal passenger protein that plays critical roles in chromosome alignment
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