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- 详细信息
- 文献和实验
- 技术资料
- 库存:
45
- 英文名:
ZM-447439
- 保质期:
半年
- 供应商:
上海联祖
- 保存条件:
-20℃避光保存
- 规格:
1mL(10mM)|5mg|10mg|50mg
| 英文名称 | 发货周期 | 产品规格 | 货号 |
| ZM-447439 | 1~3天 | 1mL(10mM)|5mg|10mg|50mg | LZ-01X7852 |
产品描述:
ZM447439是ATP竞争性Aurora A和B选择性抑制剂,IC50分别为110nM和130nM。
主要参数:
CAS号:331771-20-1
纯度:98.88%
分子量:513.59
注意事项:
注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!
储存条件:
低温运输、-20℃保存(但溶液B也可以常温运输和保存),
有效期一年。
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文献和实验The Ipl1/Aurora Kinase Family: Methods of Inhibition and Functional Analysis in Mammalian Cells
-molecule inhibitor ZM447439, RNA interference, and overexpression of a catalytic mutant. All of these methods have proved useful in studying Aurora B as well as validating it as a potential anticancer drug target. However, while all three methods are useful
A method for analyzing the ubiquitination and degradation of aurora-A
has been well characterized and it was shown that it is ubiquitin proteasome pathway that leads to the elimination of cyclins. By now, many other regulatory proteins were shown to be degraded by the same pathway, among them members of the aurora kinase family, degraded
Studying the Roles of Aurora-C Kinase During Meiosis in Mouse Oocytes
We previously isolated Aurora-C (Aurkc/Aie1 ) in a screen for kinases expressed in mouse sperm and eggs. Aurora-C kinase was reported to be a chromosomal passenger protein that plays critical roles in chromosome alignment
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