产品英文名称: Recombinant Human Secreted Phospholipase A2-X
英文简称: PLA2G10
中文名称: 重组人分泌磷脂酶A2-X
背景资料: Phospholipase A2(PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid(AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which represent another class of lipid mediators.The secretory PLA2(sPLA2) family, in which 10 isozymes have b人分泌磷脂酶A2-X重组蛋白是在大肠杆菌中重组表达的,包含有来源于人分泌磷脂酶A2-X的123个氨基酸残基,并在N末端融合一个含有16个残基的His标签,分子量为15.5kDa.该人分泌磷脂酶A2-X重组蛋白最终由标准的色谱技术纯化出.n identified, consists of low molecular weight, Ca2+-requiring secretory enzymes that have b人分泌磷脂酶A2-X重组蛋白是在大肠杆菌中重组表达的,包含有来源于人分泌磷脂酶A2-X的123个氨基酸残基,并在N末端融合一个含有16个残基的His标签,分子量为15.5kDa.该人分泌磷脂酶A2-X重组蛋白最终由标准的色谱技术纯化出.n implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, and host defense.This enzyme has b人分泌磷脂酶A2-X重组蛋白是在大肠杆菌中重组表达的,包含有来源于人分泌磷脂酶A2-X的123个氨基酸残基,并在N末端融合一个含有16个残基的His标签,分子量为15.5kDa.该人分泌磷脂酶A2-X重组蛋白最终由标准的色谱技术纯化出.n proposed to hydrolyze phosphatidylcholine(PC) in lipoproteins to liberate lyso-PC and fr人分泌磷脂酶A2-X重组蛋白是在大肠杆菌中重组表达的,包含有来源于人分泌磷脂酶A2-X的123个氨基酸残基,并在N末端融合一个含有16个残基的His标签,分子量为15.5kDa.该人分泌磷脂酶A2-X重组蛋白最终由标准的色谱技术纯化出. fatty acids in the arterial wall, thereby facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic foci.In mice, sPLA2 expression significantly influences HDL particle size and composition and demonstrate that an induction of sPLA2 is required for the decrease in plasma HDL cholesterol in response to inflammatory stimuli. Instillation of bacteria into the bronchi was associated with surfactant degradation and a decrease in large:small ratio of surfactant aMRGSHHHHHHGMASHMGILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD.regates in rats.