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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
2-8度
- 保质期:
1年
- 英文名:
GPX1
- 库存:
999
- 供应商:
上海淳麦
- 规格:
/5ug/20ug/1mg
Recombinant Human Glutathione Peroxidase 1
英文简称:
GPX1
中文名称:
重组人谷胱甘肽过氧化物酶1
背景资料:
Glutathione peroxidase 1(GPX1) is a member of the glutathione peroxidase family, consisting of 8 identified glutathione peroxidases(Gpx1-8) in humans. Glutathione peroxidase serves in the detoxification of hydrogen peroxide, and is one of the most vital antioxidant enzymes in humans. The GPX1 is a component of the enzymatic antioxidant defense, preventing oxidative damage to DNA, proteins and lipids by detoxifying hydrogen and lipid peroxides which may contribute to prostate cancer development. GPX1 is one of only a small number of proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense(stop) codon TGA. Furthermore, the GPX1 protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes 3 alleles with 5, 6 or 7 alanine(ALA) repeats in this sequence. The allele with 5 ALA repeats is significantly linked to breast cancer risk.
产品描述:
GPX1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 223 amino acids(1-203) and having a molecular mass of 24.2kDa. GPX1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达
序列:
MGSSHHHHHH SSGLVPRGSH MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLCG TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP SCA.
溶解建议:
提供的重组人谷胱甘肽过氧化物酶1产品形式为无菌的无色溶液.
保存建议:
人谷胱甘肽过氧化物酶1蛋白产品可整瓶4℃保存2-4周,长期保存请置于-20℃.推荐添加载体蛋白(0.1% HSA或BSA)以长期保存,请避免反复冻融.
其他简介:
ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列,专注于蛋白(重组及合成)生产研发,其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子,生长因子,激素,信号蛋白,病毒抗原等近800种重组蛋白和100多种抗体,是世界上提供蛋白品种最多的公司之一,领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。
上海淳麦生物为ProSpec国内代理销售经销商,详细的产品信息请和我们联系:免费热线:4006815880 微信电话 13770640776
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文献和实验chain reaction (RT-PCR) assay to investigate the effect of incubation of freshly isolated rat cardiomyocytes for 2 h at 37�C with or without 0.5 mM cysteine on the expression of cellular glutathione peroxidase (GPx1). The main analytical
Analysis of Phospholipid Hydroperoxide Glutathione Peroxidase mRNA
(6 ). In contrast, the homology between GPX1 and GPX4 is less than 40%. There are two forms of GPX4: the long form (23 kDa) with a leader sequence for transportation to mitochondria, and the short form (20 kDa) or the non-mitochondrial form (7 ). Although GPX
, CARS2, YARS2, AK3L1, LRPPRC, KARS 11 0.2898 0.02395 GO:0005739:mitochondrion MRPL40, ACOX1, D2HGDH, CCDC19, NLRX1, AK3L1, KCNJ11, KARS, GLS2, GPX1, GSR, HTRA2, CISD3, SLC25A22, HARS
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