MAPT 412a.a.

产品英文名称：
Recombinant Mouse BH3 Interacting Domain Death Agonist p15

英文简称:
mtBID

中文名称:
重组小鼠BH3结构域凋亡诱导蛋白

背景资料:
Truncated BH3 interacting domain death agonist is a truncated form of the pro-apoptotic full-length BID. Truncated BH3 interacting domain death agonist is generated by Caspase-8 cleavage of BID. The truncated form of the protein translocates from the cytosol to mitochondria and transduces apoptotic signals. BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling， BID interacts with another Bcl-2 family of cell death regulators， called Bax， they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 （CASP8）. CASP8 cleaves BID， and the COOH-terminal part translocates to mitochondria where it triers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1， Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.

产品描述:
Truncated BID Mouse Recombinant also called BH3-interacting domain death agonist p15 produced in E.Coli is a single， non-glycosylated polypeptide chain containing 61-195 amino acids （135 a.a.） and having a molecular mass of 15.4 kDa.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
Filtered colorless liquid formulation. The Mouse Truncated BID protein solution contains 10mM Tris-HCL pH-8， 1mM EDTA and 250mM NaCl.

保存建议：
tBID although stable at 15℃ for 1 week， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。