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- 2025年08月12日
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- 文献和实验
- 技术资料
- 规格：
50 µg
蛋白名称：CD59a蛋白, CD59a protein
蛋白构建：A DNA sequence encoding the mouse CD59a (NP_001104530.1) (Met 1-Lys 95),without the pro peptide, was fused with the Fc region of human IgG1 at the C-terminus.
表达宿主：HEK293 Cells
蛋白纯度：> 92 % as determined by SDS-PAGE
蛋白活性：0
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Leu 24
蛋白分子量：The secreted recombinant mouse CD59a/Fc is a disulfide-linked homodimer. The reduced monomer comprises 313 amino acids and has a calculated molecular mass of 35.4 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 42 kDa band in SDS-PAGE under reducing conditions.
蛋白NP号：NP_001104530.1
蛋白氨基酸序列：Met1-Lys95
蛋白标签：C-human IgG1-Fc
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验网络 九、CD59 CD59是近年（1989）才发现的一种分子量只有18～20kDa的膜性调节蛋白。由Sugita等（1988年）首先描述，曾有不同的名称，如同种限制因子20（homologous restriction factor-20）,保护素（protectin）及膜反应性溶破抑制物（membrane inhibitor of reactive
CD59 分子 CD59 常用单克隆抗体或代号： MEM- 43,YTH53.1;(TAP,Protectin) 主要表达细胞： 广泛 [NL] 分子质量(kDa)和结构： gp18- 20(GPI连接) 功 能： 与CD2结合,结合C8、C9,抑制MAC CD59 Aka protectin Regulates complement mediated cell lysis
Detection of CD59 Using Flow Cytometry
CD59 is the single regulator of the terminal complement pathway. It has been implicated in disease such as Paroxysmal nocturnal hemoglobinuria (PMH) and cancer. Expression of CD59 protects normal and malignant cells from the cytotoxic
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