Rab4 抗体：偶联PE/ATTO 594|Rab4 Ant

产品名称：Rab4 抗体：偶联PE/ATTO 594-Rab4 Antibody: PE/ATTO 594

产品货号：SPC-141D-P594

产品规格：100ul

应用类型：WB | IHC | ICC/IF

保存建议：Rab4 抗体：偶联PE/ATTO 594-Rab4 Antibody: PE/ATTO 594厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。

背景资料：Rab4 is a 25kDa member of the Rab family of small guanosine triphosphatases (GTPases), Ras superfamily. Rab GTPases are central regulators of membrane trafficking in the eukaryotic cell. Their regulatory capacity depends on their ability to cycle between the GDP -bound inactive and GTP-bound active states. This conversion is regulated by GDP/GTP exchange factors (GEPs), GDP dissociation inhibitors (GDIs) and GTPase-activating proteins (GAPs) (1, 2). Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a sub-cellular compartment (3). Through these proteins, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion(1). Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hyper-variable COHO-terminal domains with a cysteine motif implicated in sub-cellular targeting. Post-translational modification of the cysteine motif with one or two geranylgeranyl groups is essential for the membrane association and correct intracellular localization of Rab proteins (3). Each Rab shows a characteristic sub-cellular distribution (4).In particular, over-expression of Rab4 causes a redistribution of receptors on plasma membrane versus endocytic compartments. The presence of excessive Rab4 leads to the accumulation of tranferrin receptors in non-acidic, post-endosomal recycling vesicles considered an intermediate compartment between endosomes and plasma membranes. Rab4 also plays a role in the translocation of glucose transporter (Glu4) in adipocytes in response to insulin (5). Mediating the association of Rab4 with transferring receptor-containing early endosomes takes place through the geranylgeranyl groups at its carboxyl-terminus. Membrane association is also cell cycle dependent, as phosphorylation at its c-terminal cdc2 kinase consensus sequence in mitotic cells leads to dissociation of Rab4 into the cytosol (6).

点击：Rab4 抗体：偶联PE/ATTO 594-Rab4 Antibody: PE/ATTO 594查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询StressMarq中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍及全球50多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与a-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，StressMarq还提供全新的尖端研究工具，用于开发新的生物项目，包括全球独特的a B晶体蛋白ELISA试剂盒（现在是公认的乳腺癌标志物）；热休克同源蛋白70（Hsc70）ELISA试剂盒；以及用于神经衰退研究的Tau活性蛋白与a-突触核蛋白。本公司已将专业技术扩展到抗体、小分子离子通道与载体等更新领域，前者包括当前热门的核心领域：Nav、Cav、TRP、Kv、KCNQ、HCN，后者包括当前热门的核心领域：ENaC、NCC和NKCC2以及主要水通道蛋白载体。

艾美捷科技有限公司品线覆盖生物研究各个领域，主要包括：分子生物学（核酸蛋白研究工具、cDNA/RNA、转染试剂、植物组培/细胞培养、生化试剂及试剂盒），试剂（蛋白酶抑制剂、化合物、荧光染料/探针、动物血清）、抗体（一抗、二抗、封闭血清）， 蛋白及试剂盒（细胞因子/重组蛋白、细胞凋亡/代谢/损伤、表观遗传、天然免疫）等。艾美捷为您寻找并提供最优的产品解决方案、最完备的物流服务、最及时的售后服务。如果您对上述产品线感兴趣，请致电免费服务热线到艾美捷垂询相关产品信息及完整实验解决方案。

关键词：Rab4 Antibody: PE/ATTO 594，Rab4 抗体：偶联PE/ATTO 594，Rab4