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Tocris货号1209现货LY 341495上海睿安生物R

&D Systems-Tocris官方正式授权代理19121878899
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  • Tocris bioscience
  • 1209
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  • 2025年11月29日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 英文名

      LY 341495

    • CAS号

      201943-63-7

    • 保质期

      1年

    • 保存条件

      Room Temperature

    • 库存

      30⁺瓶

    • 供应商

      上海睿安生物19121878899

    • 规格

      10mg/瓶

    Tocris货号1209-1mg现货LY 341495上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

     

    Tocris货号1209-10mg现货LY 341495上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

    Description:Highly potent and selective group II mGlu antagonist

    Chemical Name:(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid

    Purity:≥98%

     

    Biological Activity

    LY 341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8, mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo.

     

    Disodium salt(Cat. No. 4062) also available.

    Technical Data

    M.Wt:353.37
    Formula:C20H19NO5
    Solubility:Soluble to 5 mM in DMSO with gentle warming and to 100 mM in 1.2eq. NaOH
    Purity:≥98%
    Storage:Store at RT
    CAS No:201943-63-7

    The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
    Tocris products are intended for laboratory research use only, unless stated otherwise.

     

    Background References

    1. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
      Fitzjohn et al.
      Neuropharmacology, 1998;37:1445
    2. [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
      Johnson et al.
      Neuropharmacology, 1999;38:1519
    3. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.
      Kingston et al.
      Neuropharmacology, 1998;37:1
    4. 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav
      Ornstein et al.
      J.Med.Chem., 1998;41:358
    5. 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav
      Ornstein et al.
      J.Med.Chem., 1998;41:358

     

    Citations for LY 341495(部分:文献)

    The citations listed below are publications that use Tocris products. Selected citations for LY 341495 include:

    66 Citations: Showing 1 - 10

    1.  Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
      Authors: Lafourcade Et al.
      PLoS One  ;2:e709
    2.  Regulatory system of mGluR group II in the nucleus accumbens for methamphetamine-induced DA increase by the medial prefrontal cortex.
      Authors: Haddar Et al.
      Neuropsychopharmacol Rep  2019;
    3.  Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
      Authors: Lassus Et al.
      Sci Rep  2018;8:17461
    4.  A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.
      Authors: Hellmer Et al.
      Physiol Rep  2018;6:e13885
    5.  Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters.
      Authors: Lu Et al.
      Neuron  2017;96:73
    6.  Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
      Authors: Dornier
      Nat Commun  2017;8(1):2255
    7.  Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
      Authors: Scholler
      Nat Commun  2017;8(1):1967
    8.  HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
      Authors: Scholler
      Nat Chem Biol  2017;13(4):372
    9.  Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum
      Authors: Johnson
      Neuropharmacology  2017;117:114
    10.  EXPRESS: Histone hyperacetylation modulates spinal type II metabotropic glutamate receptor alleviating stress-induced visceral hypersensitivity in female rats.
      Authors: Cao Et al.
      Mol Pain  2016;12
     Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.
    Authors: Choi Et al.
    Front Behav Neurosci  2016;10:136
     Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Mol Pain  2015;63:383
     Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    J Neurosci  2015;4
     PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
    Authors: Choi Et al.
    Psychopharmacology (Berl)  2015;35:396
     Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.
    Authors: Dunn
    Elife  2015;35:2423
     The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
    Authors: Carbonaro Et al.
    Front Neural Circuits  2015;232:275
     Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
    Authors: Johansson Et al.
    Cell Rep.  2015;13:1741
     N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans.
    Authors: Truini Et al.
    J Neurosci  2015;11:14
     Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism.
    Authors: Chen Et al.
    J Neurophysiol  2014;8:219
     VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit.
    Authors: Case Et al.
    J Neurosci  2014;8:140
     Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
    Authors: Grimes Et al.
    Elife  2014;3:e03892
     Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
    Authors: Gee Et al.
    J Biol Chem  2014;289:10975
     Modafinil attenuates reinstatement of co_caine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
    Authors: Mahler Et al.
    J Neurosci  2014;19:49
     Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to metha. via activation of group II mGluRs in mice.
    Authors: Miyamoto Et al.
    Int J Neuropsychopharmacol  2014;17:1283
     Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    Neurosci Lett  2013;8:e61787
     Properties of the ON bistratified ganglion cell in the rabbit retina.
    Authors: Hoshi Et al.
    J Comp Neurol  2013;521:1497
     Group II metabotropic glutamate receptors modify N-MthD.-aspartate receptors via Src kinase.
    Authors: Trepanier Et al.
    Sci Rep  2013;3:926
     Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
    Authors: Hulme Et al.
    J Neurosci  2012;32:6785
     Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
    Authors: Marrocco Et al.
    Acta Crystallogr Sect F Struct Biol Cryst Commun  2012;32:17143
     Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res  2012;287:43
     A non-canonical pathway for mammalian blue-green color vision.
    Authors: Sher and DeVries
    Nat Neurosci  2012;15:952
     Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model.
    Authors: Ren Et al.
    Anesthesiology  2012;116:122
     Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.
    Authors: Peachey Et al.
    Brain Res  2012;108:2442
     Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
    Authors: Taman and Ribeiro
    PLoS One  2011;6:e27119
     Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
    Authors: Johnson Et al.
    Addict Biol  2011;504:102
     A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites.
    Authors: Pearring Et al.
    Proc Natl Acad Sci U S A  2011;31:10060
     Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis.
    Authors: Jin Et al.
    Learn Mem  2011;18:96
     Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
    Authors: Ster Et al.
    J Endocrinol  2011;108:9993
     Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
    Authors: Adedoyin Et al.
    Mol Pain  2010;6:60
     Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron  2010;68:948
     Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
    Authors: Fuortes Et al.
    Epilepsia  2010;51:1633
     Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A  2010;30:3870
     Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.
    Authors: Citri Et al.
    J Neurosci  2010;30:16437
     The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
    Authors: Chen Et al.
    Psychopharmacology (Berl)  2010;209:343
     Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain.
    Authors: Muto Et al.
    Proc Natl Acad Sci U S A  2009;65:236
     N-MthD.-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    Neuropsychopharmacology  2009;30:1443
     A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.
    Authors: Sekizawa Et al.
    J Neurosci  2009;29:11807
     Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
    Authors: Carlton Et al.
    Eur J Neurosci  2009;1248:86
     Phency_clidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.
    Authors: Olszewski Et al.
    Biol Psychiatry  2008;63:86
     Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells.
    Authors: Sheffler and Conn
    Neuropharmacology  2008;55:419
     Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phency_clidine.
    Authors: Baker Et al.
    J Neurosci  2008;33:1760
     Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice.
    Authors: Huang Et al.
    J Neurosci  2008;28:7074
     Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
    Authors: Kaushal and Schlichter
    Glia  2008;28:2221
     Endocytosis and recycling of AMPA receptors lacking GluR2/3.
    Authors: Biou Et al.
    PLoS One  2008;105:1038
     Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells.
    Authors: Russo Et al.
    J Neurophysiol  2008;100:3351
     Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron  2007;54:599
     Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
    Authors: Brager and Johnston
    J Neurosci  2007;27:13926
     Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.
    Authors: Duguid Et al.
    J Neurosci  2007;27:12464
     Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
    Authors: Galici Et al.
    J Pharmacol Exp Ther  2006;318:173
     Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci  2006;26:4166
     Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol  2006;16:1591
     Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex.
    Authors: Choi Et al.
    J Neurosci  2005;25:11433
     Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well a
    Authors: Wang Et al.
    J Neurosci  2004;24:3370
     Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.
    Authors: Fujino and Oertel
    Proc Natl Acad Sci U S A  2003;100:265
     Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
    Authors: Moore Et al.
    Proc Natl Acad Sci U S A  2003;100:14397
     Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
    Authors: Nishi Et al.
    Front Behav Neurosci  2003;100:1322

       

       

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      图标文献和实验
      该产品被引用文献

      Tocris货号1209-1mg现货LY 341495上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

       

      Tocris货号1209-10mg现货LY 341495上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899

      Description:Highly potent and selective group II mGlu antagonist

      Chemical Name:(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid

      Purity:≥98%

       

      Biological Activity

      LY 341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8, mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo.

       

      Disodium salt(Cat. No. 4062) also available.

      Technical Data

      M.Wt:353.37
      Formula:C20H19NO5
      Solubility:Soluble to 5 mM in DMSO with gentle warming and to 100 mM in 1.2eq. NaOH
      Purity:≥98%
      Storage:Store at RT
      CAS No:201943-63-7

      The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
      Tocris products are intended for laboratory research use only, unless stated otherwise.

       

      Background References

      1. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
        Fitzjohn et al.
        Neuropharmacology, 1998;37:1445
      2. [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
        Johnson et al.
        Neuropharmacology, 1999;38:1519
      3. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.
        Kingston et al.
        Neuropharmacology, 1998;37:1
      4. 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav
        Ornstein et al.
        J.Med.Chem., 1998;41:358
      5. 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav
        Ornstein et al.
        J.Med.Chem., 1998;41:358

       

      Citations for LY 341495(部分:文献)

      The citations listed below are publications that use Tocris products. Selected citations for LY 341495 include:

      66 Citations: Showing 1 - 10

      1.  Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
        Authors: Lafourcade Et al.
        PLoS One  ;2:e709
      2.  Regulatory system of mGluR group II in the nucleus accumbens for methamphetamine-induced DA increase by the medial prefrontal cortex.
        Authors: Haddar Et al.
        Neuropsychopharmacol Rep  2019;
      3.  Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
        Authors: Lassus Et al.
        Sci Rep  2018;8:17461
      4.  A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.
        Authors: Hellmer Et al.
        Physiol Rep  2018;6:e13885
      5.  Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters.
        Authors: Lu Et al.
        Neuron  2017;96:73
      6.  Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
        Authors: Dornier
        Nat Commun  2017;8(1):2255
      7.  Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
        Authors: Scholler
        Nat Commun  2017;8(1):1967
      8.  HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
        Authors: Scholler
        Nat Chem Biol  2017;13(4):372
      9.  Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum
        Authors: Johnson
        Neuropharmacology  2017;117:114
      10.  EXPRESS: Histone hyperacetylation modulates spinal type II metabotropic glutamate receptor alleviating stress-induced visceral hypersensitivity in female rats.
        Authors: Cao Et al.
        Mol Pain  2016;12
       Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.
      Authors: Choi Et al.
      Front Behav Neurosci  2016;10:136
       Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
      Authors: Garthwaite Et al.
      Mol Pain  2015;63:383
       Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
      Authors: Rosa Et al.
      J Neurosci  2015;4
       PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
      Authors: Choi Et al.
      Psychopharmacology (Berl)  2015;35:396
       Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.
      Authors: Dunn
      Elife  2015;35:2423
       The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
      Authors: Carbonaro Et al.
      Front Neural Circuits  2015;232:275
       Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
      Authors: Johansson Et al.
      Cell Rep.  2015;13:1741
       N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans.
      Authors: Truini Et al.
      J Neurosci  2015;11:14
       Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism.
      Authors: Chen Et al.
      J Neurophysiol  2014;8:219
       VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit.
      Authors: Case Et al.
      J Neurosci  2014;8:140
       Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
      Authors: Grimes Et al.
      Elife  2014;3:e03892
       Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
      Authors: Gee Et al.
      J Biol Chem  2014;289:10975
       Modafinil attenuates reinstatement of co_caine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
      Authors: Mahler Et al.
      J Neurosci  2014;19:49
       Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to metha. via activation of group II mGluRs in mice.
      Authors: Miyamoto Et al.
      Int J Neuropsychopharmacol  2014;17:1283
       Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
      Authors: Wang Et al.
      Neurosci Lett  2013;8:e61787
       Properties of the ON bistratified ganglion cell in the rabbit retina.
      Authors: Hoshi Et al.
      J Comp Neurol  2013;521:1497
       Group II metabotropic glutamate receptors modify N-MthD.-aspartate receptors via Src kinase.
      Authors: Trepanier Et al.
      Sci Rep  2013;3:926
       Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
      Authors: Hulme Et al.
      J Neurosci  2012;32:6785
       Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
      Authors: Marrocco Et al.
      Acta Crystallogr Sect F Struct Biol Cryst Commun  2012;32:17143
       Intrinsic modulators of auditory thalamocortical transmission.
      Authors: Lee and Sherman
      Hear Res  2012;287:43
       A non-canonical pathway for mammalian blue-green color vision.
      Authors: Sher and DeVries
      Nat Neurosci  2012;15:952
       Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model.
      Authors: Ren Et al.
      Anesthesiology  2012;116:122
       Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.
      Authors: Peachey Et al.
      Brain Res  2012;108:2442
       Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
      Authors: Taman and Ribeiro
      PLoS One  2011;6:e27119
       Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
      Authors: Johnson Et al.
      Addict Biol  2011;504:102
       A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites.
      Authors: Pearring Et al.
      Proc Natl Acad Sci U S A  2011;31:10060
       Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis.
      Authors: Jin Et al.
      Learn Mem  2011;18:96
       Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
      Authors: Ster Et al.
      J Endocrinol  2011;108:9993
       Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
      Authors: Adedoyin Et al.
      Mol Pain  2010;6:60
       Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
      Authors: Buchanan Et al.
      Neuron  2010;68:948
       Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
      Authors: Fuortes Et al.
      Epilepsia  2010;51:1633
       Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
      Authors: Kim Et al.
      Proc Natl Acad Sci U S A  2010;30:3870
       Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.
      Authors: Citri Et al.
      J Neurosci  2010;30:16437
       The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
      Authors: Chen Et al.
      Psychopharmacology (Berl)  2010;209:343
       Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain.
      Authors: Muto Et al.
      Proc Natl Acad Sci U S A  2009;65:236
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