Tocris货号1212现货MPEP hydrochlori

 Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.
Authors: Guo Et al.
J Neurosci  2016;36:2131
 Long-Term Potentiation at the Mossy Fiber-Granule Cell Relay Invokes Postsynaptic Second-Messenger Regulation of Kv4 Channels.
Authors: Rizwan Et al.
J Neurosci  2016;36:11196
 OE Facilitation of Co_caine Self-Administration in Female Rats Requires Activation of mGluR5.
Authors: Martinez Et al.
Eneuro  2016;3
 Mechanisms of tau and Aβ-induced excitotoxicity.
Authors: Pallo Et al.
Brain Res  2016;1634:119
 Acute inhibition of mGluR5 disrupts behavioral flexibility.
Authors: Sethna and Wang
Neurobiol Learn Mem  2016;130:1
 Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.
Authors: Choi Et al.
Front Behav Neurosci  2016;10:136
 Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
Authors: Szokol Et al.
Int J Mol Sci  2015;9:49
 The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates.
Authors: Guimaraes Et al.
J Biol Chem  2015;8:24
 Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles.
Authors: Rook Et al.
Clin Exp Dermatol  2015;40:755
 Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Authors: Cramer Et al.
PLoS One  2015;35:5664
 BDNF interacts with endocannabinoids to regulate co_caine-induced synaptic plasticity in mouse midbrain DA neurons.
Authors: Zhong Et al.
J Neurosci  2015;35:4469
 Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.
Authors: Tang and Alger
J Neurosci  2015;35:3938
 Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Authors: Galván Et al.
Neuroscience  2015;290:332
 Nerve demyelination increases metabotropic glutamate receptor subtype 5 expression in peripheral painful mononeuropathy.
Authors: Ko Et al.
J Neurophysiol  2015;16:4642
 Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.
Authors: Hullinger Et al.
Neurobiol Learn Mem  2015;125:126
 Both neurons and astrocytes exhibited tetro_dotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca²⁺ oscillations in striatum.
Authors: Tamura Et al.
PLoS One  2014;9:e85351
 Hippocampal metaplasticity is required for the formation of temporal associative memories.
Authors: Xu Et al.
J Neurosci  2014;34:16762
 A novel mGluR5 antagonist, MFZ 10-7, inhibits co_caine-taking and co_caine-seeking behavior in rats.
Authors: Keck Et al.
Addict Biol  2014;19:195
 Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats.
Authors: Kumar Et al.
Behav Brain Funct  2013;9:43
 The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer.
Authors: Kuribayashi Et al.
Proc Natl Acad Sci U S A  2013;8:e80773
 Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression.
Authors: Ramiro-Cortés and Israely
PLoS One  2013;8:e71155
 NE drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.
Authors: Zhang Et al.
PLoS One  2013;8:e66122
 Group II metabotropic glutamate receptors modify N-MthD.-aspartate receptors via Src kinase.
Authors: Trepanier Et al.
Sci Rep  2013;3:926
 NE enhances a discrete form of long-term depression during fear memory storage.
Authors: Clem and Huganir
J Neurosci  2013;33:11825
 Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury.
Authors: Loane Et al.
J Neurosci  2013;30:403
 Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
Authors: Oh Et al.
Proc Natl Acad Sci U S A  2013;110:E305
 Metabotropic glutamate receptor 5 within nucleus accumbens shell modulates environment-elicited co_caine conditioning expression.
Authors: Martínez-Rivera Et al.
Pharmacol Biochem Behav  2013;110:154
 Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice.
Authors: Bozdagi Et al.
J Neurosci  2012;7:e42422
 Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine.
Authors: Beard Et al.
Vascul Pharmacol  2012;56:159
 Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia.
Authors: Mayo Et al.
J Cereb Blood Flow Metab  2012;32:825
 Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
Authors: Peterfi Et al.
J Neurosci  2012;32:14448
 Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain.
Authors: Crock Et al.
J Neurotrauma  2012;32:14217
 Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep  2012;2:285
 TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception.
Authors: Giordano Et al.
Cereb Cortex  2012;22:2495
 Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.
Authors: Zhang and Lisman
J Neurosci  2012;107:1058
 Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
Authors: Hays Et al.
J Neurosci  2011;31:14223
 Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
Authors: Zheng and Raman
J Neurosci  2011;31:10283
 Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice.
Authors: Halberstadt Et al.
Psychopharmacology (Berl)  2011;215:81
 An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
Authors: Gómez-Gonzalo Et al.
PLoS Biol  2010;8:e1000352
 Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
Authors: Tronson Et al.
Front Cell Neurosci  2010;68:1007
 The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period.
Authors: Jiang Et al.
Neuron  2010;66:248
 Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.
Authors: Price Et al.
PLoS One  2010;5:e14020
 Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
Authors: Fuortes Et al.
Epilepsia  2010;51:1633
 Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats.
Authors: Parri Et al.
Eur J Neurosci  2010;32:29
 Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.
Authors: Kolber Et al.
PLoS One  2010;30:8203
 Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.
Authors: Hammond Et al.
ACS Chem Neurosci  2010;1:702
 mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum.
Authors: Foong
Front Neurosci  2009;3:46
 Modulator property of the intrinsic cortical projection from layer 6 to layer 4.
Authors: Lee and Sherman
Front Syst Neurosci  2009;3:3
 Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials.
Authors: Kato Et al.
J Neurosci  2009;29:11153
 Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
Authors: Petzold Et al.
Neuropharmacology  2008;58:897
 Dichotomous DArgic control of striatal synaptic plasticity.
Authors: Shen Et al.
Science  2008;321:848
 In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents co_caine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression.
Authors: Grueter Et al.
J Neurosci  2008;28:9261
 Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice.
Authors: Huang Et al.
J Neurosci  2008;28:7074
 Group I metabotropic glutamate receptors control metaplasticity of spinal cord learning through a protein kinase C-dependent mechanism.
Authors: Ferguson Et al.
J Neurosci  2008;28:11939
 The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.
Authors: Zhang Et al.
J Neurosci  2008;28:10561
 Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Authors: Neyman and Manahan-Vaughan
Eur J Neurosci  2008;27:1345
 Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
Authors: Kim Et al.
J Neurosci  2008;105:4429
 AMPAR exocytosis through NO modulation of PICK1.
Authors: Sossa Et al.
Biol Psychiatry  2007;53:92
 Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.
Authors: Xu Et al.
Neuron  2007;53:399
 Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.
Authors: Bloodgood and Sabatini
Neuron  2007;53:249
 Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
Authors: Kirschstein Et al.
J Neurosci  2007;27:7696
 Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.
Authors: Muddashetty Et al.
J Neurosci  2007;27:5338
 Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
Authors: Nakamoto Et al.
Proc Natl Acad Sci U S A  2007;104:15537
 Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced co_caine seeking.
Authors: Bäckström and Hyytiä
Neuropsychopharmacology  2006;31:778
 Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by homer1a induction.
Authors: Keuren-Jensen and Cline
J Neurosci  2006;26:7575
 Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
Authors: Rancillac Et al.
Neuron  2006;26:6997
 Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci  2006;26:4318
 Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors.
Authors: Jung Et al.
Neuropsychopharmacology  2005;68:1196
 Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal.
Authors: Hashimotodani Et al.
Neuron  2005;45:257
 Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand.
Authors: Jong Et al.
Mol Pharmacol  2005;280:30469
 Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
Authors: Calò Et al.
J Neurosci  2005;25:2245
 Group I metabotropic glutamate receptor activation produces a direct excitation of identified septohippocampal cholinergic neurons.
Authors: Wu Et al.
J Neurophysiol  2004;92:1216
 Endocannabinoid-mediated metaplasticity in the hippocampus.
Authors: Chevaleyre and Castillo
Neuron  2004;43:871
 Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
Authors: Gallagher Et al.
Mol Brain  2004;24:4859
 Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons.
Authors: Melis Et al.
J Neurosci  2004;24:10707
 Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Authors: Mathiesen Et al.
Br J Pharmacol  2003;138:1026
 Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
Authors: Nishi Et al.
J Neurosci  2003;100:1322