Product overview
Description Anti-ACIN1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human ACIN1
Reactivity Human, Mouse
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol ACIN1
Full name apoptotic chromatin condensation inducer 1
Synonyms ACN; ACINUS; fSAP152
Swissprot Q9UKV3
Target Background
Apoptosis s defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Applications
Immunohistochemistry
Predicted cell location: Nucleus, Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 100-300 Predicted cell location: Nucleus, Cytoplasm
Positive control: Human esophagus cancer
Recommended dilution: 100-300
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml261222(ACIN1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml261222(ACIN1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)