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- 详细信息
- 技术资料
- 库存：
大量
- 英文名：
Aloin
- CAS号：
1415-73-2
- 保质期：
2年
- 供应商：
上海瓦兰生物
- 保存条件：
常温
- 规格：
10mg/10mM*1mL /50mg
| 规格： | 10mg | 产品价格： | ￥440.0 |
|---|---|---|---|
| 规格： | 10mM*1mL | 产品价格： | ￥600.0 |
| 规格： | 50mg | 产品价格： | ￥1760.0 |
Aloin 芦荟苷
产品简介
| 别名 | 芦荟素；(S)-5-Fluorowillardiinehydrochloride;芦荟甙A;芦荟甙;芦荟素; |
| 英文名称 | Aloin |
| CAS | 1415-73-2 |
| 规格 | 10mM*1mL (in DMSO) ; 10mg ; 50mg |
| 分子式 | C21H22O9 |
| 分子量 | 418.39 |
| 外观（性状） | Light yellow to yellow Solid |
| 储存条件 | Powder:2-8℃,2 years;Insolvent(母液):-20℃,6 months;-80℃,1 year |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 描述 | Aloin是一种蒽醌苷,具有铁螯合活性。(Aloin is an anthraquinone glycoside with iron chelating activity.) |
| SMILES | O=C1C2=C(C=CC=C2O)[C@H]([C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C4=CC(CO)=CC(O)=C14 |
| 靶点 | Others |
| In Vivo | Aloin substantially reduced tumor volumes and weight in vivo mouse xenografts, without obviously toxicity [1]. Aloin (10, 30 mg/kg bw) or vehicle was given by gavage to mice after each alcohol administration. Alcohol elevated the serum transaminases alanine aminotransferase, aspartate aminotransferase, total cholesterol and triglyceride levels which were significantly attenuated by the co-administration of aloin (p < 0.05) [3]. |
| In Vitro | Aloin significantly inhibited HUVECs proliferation, migration and tube formation in vitro. suppressed activation of VEGF receptor (VEGFR) 2 and STAT3 phosphorylation in endothelial cells. In addition, the constitutively activated STAT3 protein, and the expression of STAT3-regulated antiapoptotic (Bcl-xL), proliferative (c-Myc), and angiogenic (VEGF) proteins were also down-regulated in response to AL in human SW620 cancer cells [1].Aloin exerted inhibition of cell proliferation, adhesion and invasion abilities of B16-F10 melanoma cells under non-cytotoxic concentrations. Furthermore, aloin induced melanoma cell differentiation through the enhancement of melanogenesis and transglutaminase activity [2]. |
| 生物活性 | Aloin(Aloin-A; Barbaloin-A) is a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities. [1-3] |
| 溶解性 | Soluble in DMSO |
| EC | EINECS 215-808-0 |
| MDL | MFCD00151160 |
| InChIKey | AFHJQYHRLPMKHU-OSYMLPPYSA-N |
| InChI | InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14+,17-,19+,20-,21+/m1/s1 |
| PubChem CID | 12305761 |
| 中文名称 | 芦荟苷 |
| 通路 | Others |
是一种蒽醌苷，具有铁螯合活性。
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Aloin 芦荟苷
￥440 - 1760
