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- 2025年07月29日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
(2-Hydroxypropyl)-β-cyclodextrin
- CAS号：
128446-35-5
- 保质期：
2年
- 供应商：
上海瓦兰生物
- 保存条件：
常温
- 规格：
5G
性质
| Related Categories | Chelation/Complexation Compounds, Chemical Synthesis, Cyclodextrins, Signal Transduction Research Tools, Solubilizing Agents, 更多... |
| product line | BioReagent |
| form | powder |
| extent of labeling | 4-10 (determined by NMR) |
| solubility | H2O: 100 mg/mL |
| suitability | suitable for cell culture |
产品描述
Application
由于 HBC 和药物形成络合物，因此在水溶液中亲脂性药物的溶解度
包装
5, 10 g in poly bottle
Preparation Note
Solutions may be stored for several months at 4°C. Solid should be stored tightly sealed at room temperature.
General description
Cyclodextrins are cyclic oligosaccharides consisting of 6, 7, or 8 glucopyranose units, usually referred to as α-, β-, or γ-cyclodextrins, respectively. These compounds have rigid doughnut-shaped structures making them natural complexing agents. The unique structures of these compounds owe their stability to intramolecular hydrogen bonding between the C2- and C3-hydroxyl groups of neighboring glucopyranose units. The molecule takes on the shape of a torus with the C2- and C3-hydroxyls located around the larger opening and the more reactive C6-hydroxyl aligned around the smaller opening. The arrangement of C6-hydroxyls opposite the hydrogen bonded C2- and C3-hydroxyls forces the oxygen bonds into close proximity within the cavity, leading to an electron rich, hydrophobic interior. The size of this hydrophobic cavity is a function of the number of glucopyranose units forming the cyclodextrin.
The solubility of natural cyclodextrins is very poor. In the late 1960’s, it was discovered that chemical substitutions at the 2, 3, and 6 hydroxyl sites would greatly increase solubility. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.
Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent.
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文献和实验概要 本研究考察了粘合剂韧性和塑性流变对片剂硬度、脆碎度和顶裂的影响。使用四种不同的粘合剂，即羟丙基纤维素（HPC）、甲基纤维素（MC）、聚维酮（PVP）和预胶化淀粉，以湿法制粒的方法制备对乙酰氨基酚片（圆形弧面，600mg）。使用3个压片速度在旋转压片机上进行压片。通过径向压缩测试检测纯粘合剂片和对乙酰氨基酚片的性质。使用荷载-形变曲线下的面积衡量韧性。HPC显示出最强的韧性。HPC和MC粘合剂片剂的破裂很光洁。PVP和淀粉片剂出现顶裂和中部随机的裂纹。即使在达到最大荷载的80-90
白色粒状粉末，比重1.33－1.36。易溶于乙醇与丙酮。常用作片剂、颗粒剂的粘合剂，与蜂蜡、羟丙基纤维素、聚乙二醇——6000等配伍可用于薄膜包衣。
摩丝是泡沫状定发型的化妆品。它能使头发乌黑光亮，手感光滑，容易梳理。主要成分是水溶性高分子化合物，作用是在头发表面形成很薄的高分子膜，增加头发的刚性，使发型富有立体感，不易变形。这层高分子保护膜能溶于水，可以用水洗去。它的配方是：聚乙烯吡咯烷酮0.5～4％、羟乙基纤维素和羟丙基三甲胺苯胺盐共聚物0.5％、乙醇15％、去离子水60～65％、喷射剂15％、香精和适量防腐剂。
技术资料