Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
TIA-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function
Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Cellular Location
Cytoplasm, Stress granule. Nucleus Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage.