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146002
NK细胞抑制剂抗体
146002
多克隆
Ultra-LEAF™ Purified anti-Asialo-GM1
NK细胞抑制剂抗体
Rabbit Polyclonal IgG
大小鼠
FC
Ultra-LEAF™ Purified anti-Asialo-GM1
1ml
Cat # | Size | Price | Quantity Check Availability | Save | ||||
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146002 | 1 ml (reconstituted) |
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GM1 is a ganglioside, a type of glycosphingolipid with a single sialic acid group. Asialo-GM1 is a GM1 derivative without a sialic acid group. It is expressed on NK cells, basophils, monocytes/macrophages, and T cells. It is particularly expressed on very early thymocytes, but the expression decreases as the cells mature and become Thy-1+. The highest expression is detected on neuronal tissues. This molecule has been shown to be involved in microbial pathogenesis. Antibodies specific for Asialo-GM1 are elevated in dementia, lupus, and Guillain-Barré syndrome.
FC - Quality tested
Depletion - Reported in the literature, not verified in house
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Optimal staining for flow cytometry may vary from lot-to-lot. This antibody has been reported to deplete NK cells in vivo. A usage of 50 µl per mouse is recommended, but optimal usage will vary depending on the strain of mouse and experimental conditions2-4. It is recommended that the reagent be titrated for optimal performance for each application.
This antibody recognizes asialo-GM1. It does not react with other glycolipids, such as GM1 and Asialo-GM2.
This antibody can partially block IL-12 induced IFN-? production but does not affect other systemic action of IL-12.
This product may contain other non-IgG subtypes.
NK cells, basophils, splenic T lymphocytes, highest concentrations on neurons
1. Stein-Douglas K, et al. 1979. J. Exp. Med. 143:822.
2. Kasai M, et al. 1980. Eur. J. Immunol. 10:175.
3. Young WW Jr, et al. 1980. J. Immunol. 124:199.
4. Bansal AS, et al. 1994. J. Clin. Path. 47:300.
Cat # | Size | Price | Quantity Check Availability | Save | ||||
---|---|---|---|---|---|---|---|---|
146002 | 1 ml (reconstituted) | $485.00 |
|
GM1 is a ganglioside, a type of glycosphingolipid with a single sialic acid group. Asialo-GM1 is a GM1 derivative without a sialic acid group. It is expressed on NK cells, basophils, monocytes/macrophages, and T cells. It is particularly expressed on very early thymocytes, but the expression decreases as the cells mature and become Thy-1+. The highest expression is detected on neuronal tissues. This molecule has been shown to be involved in microbial pathogenesis. Antibodies specific for Asialo-GM1 are elevated in dementia, lupus, and Guillain-Barré syndrome.
Product DetailsFC - Quality tested
Depletion - Reported in the literature, not verified in house
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Optimal staining for flow cytometry may vary from lot-to-lot. This antibody has been reported to deplete NK cells in vivo. A usage of 50 µl per mouse is recommended, but optimal usage will vary depending on the strain of mouse and experimental conditions2-4. It is recommended that the reagent be titrated for optimal performance for each application.
This antibody recognizes asialo-GM1. It does not react with other glycolipids, such as GM1 and Asialo-GM2.
This antibody can partially block IL-12 induced IFN-? production but does not affect other systemic action of IL-12.
This product may contain other non-IgG subtypes.
NK cells, basophils, splenic T lymphocytes, highest concentrations on neurons
1. Stein-Douglas K, et al. 1979. J. Exp. Med. 143:822.
2. Kasai M, et al. 1980. Eur. J. Immunol. 10:175.
3. Young WW Jr, et al. 1980. J. Immunol. 124:199.
4. Bansal AS, et al. 1994. J. Clin. Path. 47:300.
Description | Clone | Applications |
---|---|---|
Cell Staining Buffer | FC, ICC, ICFC | |
RBC Lysis Buffer (10X) | FC, ICFC | |
TruStain FcX™ PLUS (anti-mouse CD16/32) | S17011E | FC |
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