- 询价
- 上海博湖
- BH-K20169
- 进口、国产
- 2025年07月16日
- WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
- 详见说明书
- 详见说明书
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- 详细信息
- 技术资料
- 抗体名：
胞内活化的Notch1蛋白抗体价格
- 抗体英文名：
Anti-NOTCH1/activated Notch1
- 靶点：
详见说明书
- 浓度：
1mg/1ml
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
- 宿主：
详见说明书
- 供应商：
上海博湖
- 库存：
大量
- 级别：
详见说明书
- 目录编号：
详见说明书
- 抗原来源：
Rabbit
- 保质期：
详见说明书
- 适应物种：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
Store at -20 °C
- 形态：
详见说明书
- 亚型：
IgG
- 免疫原：
KLH conjugated synthetic peptide derived from human NOTCH1/activated Notch1 (1687-1730aa)
- 规格：
0.2ml/200μg
胞内活化的Notch1蛋白抗体价格是用于化学反应、分析化验、研究实验、教学实验、化学配方使用的纯净化学品，产品品质卓越，价格实惠，多种规格供应，售后完善。
英文名称 Anti-NOTCH1/activated Notch1
中文名称 胞内活化的Notch1蛋白抗体价格
别 名 hN1; Neurogenic locus Notch homolog protein 1; activated Notch 1; activated Notch-1;Notch homolog 1 translocation associated (Drosophila); NOTCH1; TAN1; Translocation-associated Notch protein TAN-1;
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep
产品类型 一抗
研究领域 肿瘤 心血管 细胞生物 发育生物学 信号转导 干细胞 转录调节因子 表观遗传学
蛋白分子量 predicted molecular weight: 86/89/271kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human NOTCH1/activated Notch1 (1687-1730aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
胞内活化的Notch1蛋白抗体价格产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The LIN-12/notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for notch include Jagged1, Jagged2 and Delta. Jagged can activate notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions. Normal Delta expression is restricted to the adrenal gland and placenta. Delta expression has also been found in neuroendocrine tumors such as neuroblastomas and pheochromocytomas.
Function : Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. The protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands. Once the Notch extracellular domain interacts with a ligand, a protease called TACE (Tumor Necrosis Factor Alpha Converting Enzyme) cleaves the Notch protein just outside the membrane. This releases the extracellular portion of Notch, which continues to interact with the ligand. The ligand plus the Notch extracellular domain is then endocytosed by the ligand expressing cell. After this first cleavage, an enzyme called gamma-secretase cleaves the remaining part of the Notch protein just inside the inner leaflet of the cell membrane. This releases the intracellular portion of the Notch protein, which then moves to the nucleus and causes various genes to be expressed. There are many other proteins involved in the intracellular portion of the Notch signalling cascade.Subunit : Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiationSubcellular Location : Cell membrane; Single-pass type I membrane protein (By similarity).Notch 1 intracellular domain: Nucleus (By similarity). Note=Following proteolytical processing NICD is translocated to the nucleusTissue Specificity : In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.Post-translational modifications : Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). Following endocytosis, this fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).Phosphorylated (By similarity).O-glycosylated on the EGF-like domains. Contains both O-linked fucose and O-linked glucose.Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. Monoubiquitination at Lys-1759 is required for activation by gamma-secretase cleavage, it promotes interaction with AAK1, which stabilizes it. Deubiquitination by EIF3F is necessary for nuclear import of activated Notch.Hydroxylated at Asn-1955 by HIF1AN. Hydroxylated at Asn-2022 by HIF1AN (By similarity). Hydroxylation reduces affinity for HI1AN and may thus indirectly modulate negative regulation of NICDDISEASE : Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:109730]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.Similarity : Belongs to the NOTCH family.Contains 5 ANK repeats.Contains 36 EGF-like domains.Contains 3 LNR (Lin/Notch) repeats.Database links : UniProtKB/Swiss-Prot: P46531.4
胞内活化的Notch1蛋白抗体价格具有全、新、优、品、好四大特点：
全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。
新：产品更新速度较快，基本上每周都有新产品出现。
优：产品质量好，投诉比较少。
好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。
我们提供的标记服务，可根据您科研的需求，满足您的需要，质量保证，价格合理。
一、标记流程
委托标记服务，请下载并详细填写《委托标记申请单》，待我公司标记室技术人员研究、确认后答复，并办理委托标记事宜。
二、各种标记物制备的收费标准（RMB）
我们不但提供抗体和大分子蛋白的标记服务，还提供小分子多肽及小分子蛋白的各种标记服务，提供标记化合物的服务（此化合物必须适用于标记），价格另议。
一抗和二坑的区别：
第一抗体就是平常所说的抗体，即能和抗原特异性结合。
第二抗体是能和抗体结合的，即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体，二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说，抗原进入机体刺激机体免疫系统产生免疫应答，由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团，而且一抗可以至少结合两种其他基团（底物和二抗）。
一抗：可以特异结合底物，就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗：可以和一抗结合，并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），作用是检测一抗。 如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），则不需要二抗。但这样成本很高，因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记，再来检测一抗。而一抗识别底物。这样，当一抗结合到底物上，就可以通过二抗检测出来。
Immunoprecipitation/ IP Kit - Anti-GGCT Immunomagnetic Beads IP 5 mL
Immunoprecipitation/ IP Kit - Anti-COL4A3BP Immunomagnetic Beads IP 5 mL
Immunoprecipitation/ IP Kit - Anti-ENSA / Endosulfine alpha Immunomagnetic Beads IP 5 mL
Immunoprecipita
TRIM28 抗體, 兔多抗, 抗原親和純化 WB IHC-P IP 50 µg
Nac1 抗體, 兔多抗, 抗原親和純化 IHC-P 50 µg
Piwil2 抗體, 兔多抗, 抗原親和純化 IHC-P IF ICC/IF 50 µg
BLyS / TNFSF13B / BAFF 抗體, 兔單抗 WB FCM IP 50 µg
BLyS / TNFSF13B 抗體, 兔單抗 ELISA 50 µg
CD80 / B7-1 抗體, 兔多抗, 抗原親和純化 ELISA 50 µg
Tie2 / CD202b / TEK 抗體, 兔單抗 FCM IF ICC/IF 50 µg
CSF2RA / GM-CSFR / CD116 抗體, 鼠單抗 ELISA 50 µL
Tie2 / CD202b / TEK 抗體 (PE), 兔單抗 FCM 25 Test
TEK / Tie2 / CD202b 抗體, 兔多抗, 抗原親和純化 ELISA 50 µg
细菌培养基的选择性抑制剂 去氧胆酸钠 100g
用于革兰氏阴性肠道菌的选择性分离和平板计数。 去氧胆酸盐琼脂 250g
用于金黄色葡萄球菌、溶血性链球菌和蜡样芽孢杆菌的培养（GB标准） 肉浸液肉汤 250g
用于培养基、生物发酵的原材料 肉胃蛋白酶消化物 25kg
用于培养基、生物发酵的原材料 肉胰酶消化物 2型 25kg
卵黄氯化钠琼脂培养基 250g
溴化十六烷基三甲铵琼脂培养基（2015药典） 250g
酵母浸出粉胨葡萄糖琼脂培养基（YPD） 250g
乳糖发酵培养基 250g
曙红亚蓝琼脂培养基（EMB） 250g
胞内活化的Notch1蛋白抗体价格人胃泌素释放多肽(GRP)ELISA试剂盒 15.6-1000 pg/mL
ELISA Kit for Human Gastrin-releasing peptide 15.6-1000 pg/mL
人G蛋白偶联雌激素受体1(G-protein coupled estrogen receptor 1)ELISA试剂盒 0.312-20 ng/mL
ELISA Kit for Human G-protein coupled estrogen receptor 1 0.312-20 ng/mL
小鼠甘丙肽多肽(Galanin peptides)ELISA试剂盒 7.8-500 pg/mL
英文名称 Anti-NOTCH1/activated Notch1
中文名称 胞内活化的Notch1蛋白抗体价格
别 名 hN1; Neurogenic locus Notch homolog protein 1; activated Notch 1; activated Notch-1;Notch homolog 1 translocation associated (Drosophila); NOTCH1; TAN1; Translocation-associated Notch protein TAN-1;
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep
产品类型 一抗
研究领域 肿瘤 心血管 细胞生物 发育生物学 信号转导 干细胞 转录调节因子 表观遗传学
蛋白分子量 predicted molecular weight: 86/89/271kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human NOTCH1/activated Notch1 (1687-1730aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
胞内活化的Notch1蛋白抗体价格产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The LIN-12/notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for notch include Jagged1, Jagged2 and Delta. Jagged can activate notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions. Normal Delta expression is restricted to the adrenal gland and placenta. Delta expression has also been found in neuroendocrine tumors such as neuroblastomas and pheochromocytomas.
Function : Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. The protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands. Once the Notch extracellular domain interacts with a ligand, a protease called TACE (Tumor Necrosis Factor Alpha Converting Enzyme) cleaves the Notch protein just outside the membrane. This releases the extracellular portion of Notch, which continues to interact with the ligand. The ligand plus the Notch extracellular domain is then endocytosed by the ligand expressing cell. After this first cleavage, an enzyme called gamma-secretase cleaves the remaining part of the Notch protein just inside the inner leaflet of the cell membrane. This releases the intracellular portion of the Notch protein, which then moves to the nucleus and causes various genes to be expressed. There are many other proteins involved in the intracellular portion of the Notch signalling cascade.Subunit : Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiationSubcellular Location : Cell membrane; Single-pass type I membrane protein (By similarity).Notch 1 intracellular domain: Nucleus (By similarity). Note=Following proteolytical processing NICD is translocated to the nucleusTissue Specificity : In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.Post-translational modifications : Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). Following endocytosis, this fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).Phosphorylated (By similarity).O-glycosylated on the EGF-like domains. Contains both O-linked fucose and O-linked glucose.Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. Monoubiquitination at Lys-1759 is required for activation by gamma-secretase cleavage, it promotes interaction with AAK1, which stabilizes it. Deubiquitination by EIF3F is necessary for nuclear import of activated Notch.Hydroxylated at Asn-1955 by HIF1AN. Hydroxylated at Asn-2022 by HIF1AN (By similarity). Hydroxylation reduces affinity for HI1AN and may thus indirectly modulate negative regulation of NICDDISEASE : Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:109730]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.Similarity : Belongs to the NOTCH family.Contains 5 ANK repeats.Contains 36 EGF-like domains.Contains 3 LNR (Lin/Notch) repeats.Database links : UniProtKB/Swiss-Prot: P46531.4
胞内活化的Notch1蛋白抗体价格具有全、新、优、品、好四大特点：
全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。
新：产品更新速度较快，基本上每周都有新产品出现。
优：产品质量好，投诉比较少。
好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。
我们提供的标记服务，可根据您科研的需求，满足您的需要，质量保证，价格合理。
一、标记流程
委托标记服务，请下载并详细填写《委托标记申请单》，待我公司标记室技术人员研究、确认后答复，并办理委托标记事宜。
二、各种标记物制备的收费标准（RMB）
我们不但提供抗体和大分子蛋白的标记服务，还提供小分子多肽及小分子蛋白的各种标记服务，提供标记化合物的服务（此化合物必须适用于标记），价格另议。
一抗和二坑的区别：
第一抗体就是平常所说的抗体，即能和抗原特异性结合。
第二抗体是能和抗体结合的，即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体，二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说，抗原进入机体刺激机体免疫系统产生免疫应答，由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团，而且一抗可以至少结合两种其他基团（底物和二抗）。
一抗：可以特异结合底物，就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗：可以和一抗结合，并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），作用是检测一抗。 如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），则不需要二抗。但这样成本很高，因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记，再来检测一抗。而一抗识别底物。这样，当一抗结合到底物上，就可以通过二抗检测出来。
Immunoprecipitation/ IP Kit - Anti-GGCT Immunomagnetic Beads IP 5 mL
Immunoprecipitation/ IP Kit - Anti-COL4A3BP Immunomagnetic Beads IP 5 mL
Immunoprecipitation/ IP Kit - Anti-ENSA / Endosulfine alpha Immunomagnetic Beads IP 5 mL
Immunoprecipita
TRIM28 抗體, 兔多抗, 抗原親和純化 WB IHC-P IP 50 µg
Nac1 抗體, 兔多抗, 抗原親和純化 IHC-P 50 µg
Piwil2 抗體, 兔多抗, 抗原親和純化 IHC-P IF ICC/IF 50 µg
BLyS / TNFSF13B / BAFF 抗體, 兔單抗 WB FCM IP 50 µg
BLyS / TNFSF13B 抗體, 兔單抗 ELISA 50 µg
CD80 / B7-1 抗體, 兔多抗, 抗原親和純化 ELISA 50 µg
Tie2 / CD202b / TEK 抗體, 兔單抗 FCM IF ICC/IF 50 µg
CSF2RA / GM-CSFR / CD116 抗體, 鼠單抗 ELISA 50 µL
Tie2 / CD202b / TEK 抗體 (PE), 兔單抗 FCM 25 Test
TEK / Tie2 / CD202b 抗體, 兔多抗, 抗原親和純化 ELISA 50 µg
细菌培养基的选择性抑制剂 去氧胆酸钠 100g
用于革兰氏阴性肠道菌的选择性分离和平板计数。 去氧胆酸盐琼脂 250g
用于金黄色葡萄球菌、溶血性链球菌和蜡样芽孢杆菌的培养（GB标准） 肉浸液肉汤 250g
用于培养基、生物发酵的原材料 肉胃蛋白酶消化物 25kg
用于培养基、生物发酵的原材料 肉胰酶消化物 2型 25kg
卵黄氯化钠琼脂培养基 250g
溴化十六烷基三甲铵琼脂培养基（2015药典） 250g
酵母浸出粉胨葡萄糖琼脂培养基（YPD） 250g
乳糖发酵培养基 250g
曙红亚蓝琼脂培养基（EMB） 250g
胞内活化的Notch1蛋白抗体价格人胃泌素释放多肽(GRP)ELISA试剂盒 15.6-1000 pg/mL
ELISA Kit for Human Gastrin-releasing peptide 15.6-1000 pg/mL
人G蛋白偶联雌激素受体1(G-protein coupled estrogen receptor 1)ELISA试剂盒 0.312-20 ng/mL
ELISA Kit for Human G-protein coupled estrogen receptor 1 0.312-20 ng/mL
小鼠甘丙肽多肽(Galanin peptides)ELISA试剂盒 7.8-500 pg/mL
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胞内活化的Notch1蛋白抗体价格
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