- ¥2980
- LMAI Bio
- LM-11514R-FITC
- 中国/美国/欧洲
- 2025年07月14日
- ICC=1:50-200 IF=1:50-200
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 靶点：
详见说明书
- 级别：
1
- 目录编号：
LM-11514R-FITC
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Anti-CCKAR/FITC
- 抗体名：
Anti-CCKAR/FITC
- 标记物：
FITC标记
- 宿主：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 免疫原：
详见说明书
- 亚型：
IGg
- 形态：
粉末、液体、冻干粉
- 应用范围：
ICC=1:50-200 IF=1:50-200
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
| 英文名称 | Anti-CCKAR/FITC |
| 中文名称 | FITC标记的胆囊收缩素A受体抗体 |
| 别 名 | CCK A; CCK A receptor; CCK AR; CCK-AR; CCKAR_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCKAR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction. Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 886 Human Entrez Gene: 12425 Mouse Entrez Gene: 24889 Rat Omim: 118444 Human SwissProt: P32238 Human SwissProt: O08786 Mouse SwissProt: P30551 Rat Unigene: 129 Human Unigene: 3521 Mouse Unigene: 10184 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验技术原理与方法｜超级色差校正物镜 PLAPON60XOSC 在脑组织四重免疫荧光分析中的应用
染色（Alexa Fluor405，蓝色）；CB1 染色（Alexa Fluor488，绿色）；VIP 染色（Cy3，红色）；DGLα染色（Alexa Fluor647，白色）。 GABAergic 篮状细胞有两种表达大麻素受体 CB1 并控制锥体细胞躯体的亚型，一种亚型表达胆囊收缩素（CCK），另一种表达血管活性肠肽（VIP）。这种四重免疫荧光染色显示，在高表达 CB1（绿色）和 VIAAT（蓝色）的阳性神经末梢（红色）周围缺乏 DGLα（白色），其表明 VIP 阳性神经末梢不参与侵入性突触
自己知识产权的人类新基因,前期的功能研究表明,它是促进细胞凋亡的增强剂.利用荧光 素(FITC)标记的TFAR19单克隆抗体为探针,对细胞凋亡过程中TFAR19蛋白的表达水平及定位研究发现,凋亡早期TFAR19表达水平增高并出 现快速核转位现象...查看原文 了解更多有用的、有意思的前沿资讯以及酷炫的实验方法,可以向大师兄申请微信好友 师兄微信号:shixiongcoming
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氯离子泵功能的嗜盐菌紫质（halorhodopsin）在十二指肠上皮细胞中的胆囊收缩素（Cck）启动子下表达。当被 532 nm 光触发时，halorhodopsin 可以使细胞膜超极化，立即沉默电兴奋细胞。 在 CckCRE_Halo 小鼠中，迷走神经对腔内蔗糖、α-MGP 和三氯蔗糖的反应在对照 473nm 光存在下保持不变。然而，在 532 nm 光刺激下，对相同刺激的迷走神经反应完全消失，表明迷走神经反应取决于十二指肠 CCK 标记的 Neuropod 细胞。 图片来源：Nature
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